Mapping pathological phenotypes in a mouse model of CDKL5 disorder.

Mapping pathological phenotypes in a mouse model of CDKL5 disorder.

Mutations in cyclin-dependent kinase-like 5 (CDKL5) cause early-onset epileptic encephalopathy, a neurodevelopmental disorder with similarities to Rett Syndrome. Here we describe the physiological, molecular, and behavioral phenotyping of a Cdkl5 conditional knockout mouse model of CDKL5 disorder. B...

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Main Authors: Elena Amendola, Yang Zhan, Camilla Mattucci, Enrico Castroflorio, Eleonora Calcagno, Claudia Fuchs, Giuseppina Lonetti, Davide Silingardi, Alexei L Vyssotski, Dominika Farley, Elisabetta Ciani, Tommaso Pizzorusso, Maurizio Giustetto, Cornelius T Gross
Format: article
Language:EN
Published: Public Library of Science (PLoS) 2014
Subjects:
Medicine
R
Science
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Online Access:https://doaj.org/article/d45b19ecb62749ff9f027ee1b74272dc
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https://doaj.org/article/d45b19ecb62749ff9f027ee1b74272dc

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