Development of phenotypic assays for identifying novel blockers of L-type calcium channels in neurons

Abstract L-type calcium channels (LTCCs) are highly expressed in the heart and brain and are critical for cardiac and neuronal functions. LTCC-blocking drugs have a long and successful record in the clinic for treating cardiovascular disorders. In contrast, establishment of their efficacy for indica...

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Autores principales: Rebecca Hagan, Elizabeth Rex, David Woody, Monika Milewski, Thomas Glaza, Michael P. Maher, Yi Liu
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/d47221df885344dc960f53333798321c
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