Loss of MAX results in meiotic entry in mouse embryonic and germline stem cells

The mechanisms that trigger meiosis in germ cells and halt this process in non-germline cells are unclear. Here, the authors show that knockout of Maxin embryonic stem cells results in meiotic onset in a mechanism that involves the PRC1 complex.

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Detalles Bibliográficos
Autores principales: Ayumu Suzuki, Masataka Hirasaki, Tomoaki Hishida, Jun Wu, Daiji Okamura, Atsushi Ueda, Masazumi Nishimoto, Yutaka Nakachi, Yosuke Mizuno, Yasushi Okazaki, Yasuhisa Matsui, Juan Carlos Izpisua Belmonte, Akihiko Okuda
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2016
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Acceso en línea:https://doaj.org/article/d48b7e92a9494f59a69114f0d697881b
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