Discovery of new TLR7 agonists by a combination of statistical learning-based QSAR, virtual screening, and molecular dynamics

Search for new antiviral medications has surged in the past two years due to the COVID-19 crisis. Toll-like receptor 7 (TLR7) is among one of the most important TLR proteins of innate immunity that is responsible for broad antiviral response and immune system control. TLR7 agonists, as both vaccine...

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Autores principales: Ardavan Abiri, Masoud Rezaei, Mohammad Hossein Zeighami, Younes Vaezpour, Leili Dehghan, Maedeh KhorramGhahfarokhi
Formato: article
Lenguaje:EN
Publicado: Elsevier 2021
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Acceso en línea:https://doaj.org/article/d4b8ad598b8a4ec79183a44ac3cc0543
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