Nucleolar expansion and elevated protein translation in premature aging

HGPS is a premature aging disease caused by mutations in the nuclear protein lamin A. Here, the authors show that cells from patients with HGPS have expanded nucleoli and increased protein synthesis, and report that nucleoli also expand as aging progresses in cells derived from healthy individuals.

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Autores principales: Abigail Buchwalter, Martin W. Hetzer
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
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Acceso en línea:https://doaj.org/article/d4be55ed5c864b928f60c52944acc1b7
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