Nucleolar expansion and elevated protein translation in premature aging

HGPS is a premature aging disease caused by mutations in the nuclear protein lamin A. Here, the authors show that cells from patients with HGPS have expanded nucleoli and increased protein synthesis, and report that nucleoli also expand as aging progresses in cells derived from healthy individuals.

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Detalles Bibliográficos
Autores principales:	Abigail Buchwalter, Martin W. Hetzer
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/d4be55ed5c864b928f60c52944acc1b7
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spelling	oai:doaj.org-article:d4be55ed5c864b928f60c52944acc1b72021-12-02T14:40:23ZNucleolar expansion and elevated protein translation in premature aging10.1038/s41467-017-00322-z2041-1723https://doaj.org/article/d4be55ed5c864b928f60c52944acc1b72017-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-00322-zhttps://doaj.org/toc/2041-1723HGPS is a premature aging disease caused by mutations in the nuclear protein lamin A. Here, the authors show that cells from patients with HGPS have expanded nucleoli and increased protein synthesis, and report that nucleoli also expand as aging progresses in cells derived from healthy individuals.Abigail BuchwalterMartin W. HetzerNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-13 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Abigail Buchwalter Martin W. Hetzer Nucleolar expansion and elevated protein translation in premature aging
description	HGPS is a premature aging disease caused by mutations in the nuclear protein lamin A. Here, the authors show that cells from patients with HGPS have expanded nucleoli and increased protein synthesis, and report that nucleoli also expand as aging progresses in cells derived from healthy individuals.
format	article
author	Abigail Buchwalter Martin W. Hetzer
author_facet	Abigail Buchwalter Martin W. Hetzer
author_sort	Abigail Buchwalter
title	Nucleolar expansion and elevated protein translation in premature aging
title_short	Nucleolar expansion and elevated protein translation in premature aging
title_full	Nucleolar expansion and elevated protein translation in premature aging
title_fullStr	Nucleolar expansion and elevated protein translation in premature aging
title_full_unstemmed	Nucleolar expansion and elevated protein translation in premature aging
title_sort	nucleolar expansion and elevated protein translation in premature aging
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/d4be55ed5c864b928f60c52944acc1b7
work_keys_str_mv	AT abigailbuchwalter nucleolarexpansionandelevatedproteintranslationinprematureaging AT martinwhetzer nucleolarexpansionandelevatedproteintranslationinprematureaging
_version_	1718390326837641216

Nucleolar expansion and elevated protein translation in premature aging

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