Eletrophilic Chemistry of Tranilast Is Involved in Its Anti-Colitic Activity via Nrf2-HO-1 Pathway Activation

Eletrophilic Chemistry of Tranilast Is Involved in Its Anti-Colitic Activity via Nrf2-HO-1 Pathway Activation

Tranilast (TRL), a synthetic derivative of a tryptophan metabolite, is an anti-allergic drug used to treat bronchial asthma. We investigated how TRL activated the nuclear factor-erythroid 2 p45-related factor 2 (Nrf2)-hemeoxygenase-1 (HO-1) pathway based on the electrophilic chemistry of the drug an...

Description complète

Enregistré dans:
Détails bibliographiques
Auteurs principaux: Seongkeun Jeong, Changyu Kang, Sohee Park, Sanghyun Ju, Jin-Wook Yoo, In-Soo Yoon, Hwayoung Yun, Yunjin Jung
Format: article
Langue:EN
Publié: MDPI AG 2021
Sujets:
tranilast
electrophile
Nrf2
HO-1
colitis
Medicine
R
Pharmacy and materia medica
RS1-441
Accès en ligne:https://doaj.org/article/d4c7830b0e65428d8b8d171c5bd527fb
Tags: Ajouter un tag
Pas de tags, Soyez le premier à ajouter un tag!

Internet

https://doaj.org/article/d4c7830b0e65428d8b8d171c5bd527fb

Documents similaires