Eletrophilic Chemistry of Tranilast Is Involved in Its Anti-Colitic Activity via Nrf2-HO-1 Pathway Activation

Eletrophilic Chemistry of Tranilast Is Involved in Its Anti-Colitic Activity via Nrf2-HO-1 Pathway Activation

Tranilast (TRL), a synthetic derivative of a tryptophan metabolite, is an anti-allergic drug used to treat bronchial asthma. We investigated how TRL activated the nuclear factor-erythroid 2 p45-related factor 2 (Nrf2)-hemeoxygenase-1 (HO-1) pathway based on the electrophilic chemistry of the drug an...

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Autores principales: Seongkeun Jeong, Changyu Kang, Sohee Park, Sanghyun Ju, Jin-Wook Yoo, In-Soo Yoon, Hwayoung Yun, Yunjin Jung
Formato: article
Lenguaje:EN
Publicado: MDPI AG 2021
Materias:
tranilast
electrophile
Nrf2
HO-1
colitis
Medicine
R
Pharmacy and materia medica
RS1-441
Acceso en línea:https://doaj.org/article/d4c7830b0e65428d8b8d171c5bd527fb
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https://doaj.org/article/d4c7830b0e65428d8b8d171c5bd527fb

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