Functionally Overlapping Variants Control Tuberculosis Susceptibility in Collaborative Cross Mice

Functionally Overlapping Variants Control Tuberculosis Susceptibility in Collaborative Cross Mice

ABSTRACT Host genetics plays an important role in determining the outcome of Mycobacterium tuberculosis infection. We previously found that Collaborative Cross (CC) mouse strains differ in their susceptibility to M. tuberculosis and that the CC042/GeniUnc (CC042) strain suffered from a rapidly progr...

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Bibliographic Details
Main Authors: Clare M. Smith, Megan K. Proulx, Rocky Lai, Michael C. Kiritsy, Timothy A. Bell, Pablo Hock, Fernando Pardo-Manuel de Villena, Martin T. Ferris, Richard E. Baker, Samuel M. Behar, Christopher M. Sassetti
Format: article
Language:EN
Published: American Society for Microbiology 2019
Subjects:
Mycobacterium tuberculosis
adaptive immunity
Collaborative Cross mice
host genetics
host response
host-pathogen interactions
Microbiology
QR1-502
Online Access:https://doaj.org/article/d4cab79506754b9ea4ff592ecc872668
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https://doaj.org/article/d4cab79506754b9ea4ff592ecc872668

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