Functionally Overlapping Variants Control Tuberculosis Susceptibility in Collaborative Cross Mice

Functionally Overlapping Variants Control Tuberculosis Susceptibility in Collaborative Cross Mice

ABSTRACT Host genetics plays an important role in determining the outcome of Mycobacterium tuberculosis infection. We previously found that Collaborative Cross (CC) mouse strains differ in their susceptibility to M. tuberculosis and that the CC042/GeniUnc (CC042) strain suffered from a rapidly progr...

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Autores principales: Clare M. Smith, Megan K. Proulx, Rocky Lai, Michael C. Kiritsy, Timothy A. Bell, Pablo Hock, Fernando Pardo-Manuel de Villena, Martin T. Ferris, Richard E. Baker, Samuel M. Behar, Christopher M. Sassetti
Formato: article
Lenguaje:EN
Publicado: American Society for Microbiology 2019
Materias:
Mycobacterium tuberculosis
adaptive immunity
Collaborative Cross mice
host genetics
host response
host-pathogen interactions
Microbiology
QR1-502
Acceso en línea:https://doaj.org/article/d4cab79506754b9ea4ff592ecc872668
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https://doaj.org/article/d4cab79506754b9ea4ff592ecc872668

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