Exosome-delivered EGFR regulates liver microenvironment to promote gastric cancer liver metastasis

EGFR signalling has been linked to cancer development but whether it has any role in pre-metastatic niche formation is not known. Here the authors show that gastric cancer cells send EGFR through exosomes to the liver where it causes the establishment of a favourable microenvironment thus promoting...

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Autores principales:	Haiyang Zhang, Ting Deng, Rui Liu, Ming Bai, Likun Zhou, Xia Wang, Shuang Li, Xinyi Wang, Haiou Yang, Jialu Li, Tao Ning, Dingzhi Huang, Hongli Li, Le Zhang, Guoguang Ying, Yi Ba
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/d4d3d21a7c36464a8fb02e163d543374
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

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spelling	oai:doaj.org-article:d4d3d21a7c36464a8fb02e163d5433742021-12-02T17:06:29ZExosome-delivered EGFR regulates liver microenvironment to promote gastric cancer liver metastasis10.1038/ncomms150162041-1723https://doaj.org/article/d4d3d21a7c36464a8fb02e163d5433742017-04-01T00:00:00Zhttps://doi.org/10.1038/ncomms15016https://doaj.org/toc/2041-1723EGFR signalling has been linked to cancer development but whether it has any role in pre-metastatic niche formation is not known. Here the authors show that gastric cancer cells send EGFR through exosomes to the liver where it causes the establishment of a favourable microenvironment thus promoting metastasis.Haiyang ZhangTing DengRui LiuMing BaiLikun ZhouXia WangShuang LiXinyi WangHaiou YangJialu LiTao NingDingzhi HuangHongli LiLe ZhangGuoguang YingYi BaNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-11 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Haiyang Zhang Ting Deng Rui Liu Ming Bai Likun Zhou Xia Wang Shuang Li Xinyi Wang Haiou Yang Jialu Li Tao Ning Dingzhi Huang Hongli Li Le Zhang Guoguang Ying Yi Ba Exosome-delivered EGFR regulates liver microenvironment to promote gastric cancer liver metastasis
description	EGFR signalling has been linked to cancer development but whether it has any role in pre-metastatic niche formation is not known. Here the authors show that gastric cancer cells send EGFR through exosomes to the liver where it causes the establishment of a favourable microenvironment thus promoting metastasis.
format	article
author	Haiyang Zhang Ting Deng Rui Liu Ming Bai Likun Zhou Xia Wang Shuang Li Xinyi Wang Haiou Yang Jialu Li Tao Ning Dingzhi Huang Hongli Li Le Zhang Guoguang Ying Yi Ba
author_facet	Haiyang Zhang Ting Deng Rui Liu Ming Bai Likun Zhou Xia Wang Shuang Li Xinyi Wang Haiou Yang Jialu Li Tao Ning Dingzhi Huang Hongli Li Le Zhang Guoguang Ying Yi Ba
author_sort	Haiyang Zhang
title	Exosome-delivered EGFR regulates liver microenvironment to promote gastric cancer liver metastasis
title_short	Exosome-delivered EGFR regulates liver microenvironment to promote gastric cancer liver metastasis
title_full	Exosome-delivered EGFR regulates liver microenvironment to promote gastric cancer liver metastasis
title_fullStr	Exosome-delivered EGFR regulates liver microenvironment to promote gastric cancer liver metastasis
title_full_unstemmed	Exosome-delivered EGFR regulates liver microenvironment to promote gastric cancer liver metastasis
title_sort	exosome-delivered egfr regulates liver microenvironment to promote gastric cancer liver metastasis
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/d4d3d21a7c36464a8fb02e163d543374
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Exosome-delivered EGFR regulates liver microenvironment to promote gastric cancer liver metastasis

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