Integrative genomic and transcriptomic analysis of leiomyosarcoma

The molecular genetic landscape of leiomyosarcoma (LMS) is largely unknown. Here, the authors identify frequent DNA copy number alterations, whole-genome duplication, TP53 and RB1 inactivation, alternative telomere lengthening, and genomic imprints of defective DNA repair via homologous recombinatio...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Priya Chudasama, Sadaf S. Mughal, Mathijs A. Sanders, Daniel Hübschmann, Inn Chung, Katharina I. Deeg, Siao-Han Wong, Sophie Rabe, Mario Hlevnjak, Marc Zapatka, Aurélie Ernst, Kortine Kleinheinz, Matthias Schlesner, Lina Sieverling, Barbara Klink, Evelin Schröck, Remco M. Hoogenboezem, Bernd Kasper, Christoph E. Heilig, Gerlinde Egerer, Stephan Wolf, Christof von Kalle, Roland Eils, Albrecht Stenzinger, Wilko Weichert, Hanno Glimm, Stefan Gröschel, Hans-Georg Kopp, Georg Omlor, Burkhard Lehner, Sebastian Bauer, Simon Schimmack, Alexis Ulrich, Gunhild Mechtersheimer, Karsten Rippe, Benedikt Brors, Barbara Hutter, Marcus Renner, Peter Hohenberger, Claudia Scholl, Stefan Fröhling
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/d4d8c497353f4a34a7f3673b1d82cb28
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:d4d8c497353f4a34a7f3673b1d82cb28
record_format	dspace
spelling	oai:doaj.org-article:d4d8c497353f4a34a7f3673b1d82cb282021-12-02T14:40:05ZIntegrative genomic and transcriptomic analysis of leiomyosarcoma10.1038/s41467-017-02602-02041-1723https://doaj.org/article/d4d8c497353f4a34a7f3673b1d82cb282018-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-02602-0https://doaj.org/toc/2041-1723The molecular genetic landscape of leiomyosarcoma (LMS) is largely unknown. Here, the authors identify frequent DNA copy number alterations, whole-genome duplication, TP53 and RB1 inactivation, alternative telomere lengthening, and genomic imprints of defective DNA repair via homologous recombination as a potential therapeutic target in LMS patients.Priya ChudasamaSadaf S. MughalMathijs A. SandersDaniel HübschmannInn ChungKatharina I. DeegSiao-Han WongSophie RabeMario HlevnjakMarc ZapatkaAurélie ErnstKortine KleinheinzMatthias SchlesnerLina SieverlingBarbara KlinkEvelin SchröckRemco M. HoogenboezemBernd KasperChristoph E. HeiligGerlinde EgererStephan WolfChristof von KalleRoland EilsAlbrecht StenzingerWilko WeichertHanno GlimmStefan GröschelHans-Georg KoppGeorg OmlorBurkhard LehnerSebastian BauerSimon SchimmackAlexis UlrichGunhild MechtersheimerKarsten RippeBenedikt BrorsBarbara HutterMarcus RennerPeter HohenbergerClaudia SchollStefan FröhlingNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-15 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Priya Chudasama Sadaf S. Mughal Mathijs A. Sanders Daniel Hübschmann Inn Chung Katharina I. Deeg Siao-Han Wong Sophie Rabe Mario Hlevnjak Marc Zapatka Aurélie Ernst Kortine Kleinheinz Matthias Schlesner Lina Sieverling Barbara Klink Evelin Schröck Remco M. Hoogenboezem Bernd Kasper Christoph E. Heilig Gerlinde Egerer Stephan Wolf Christof von Kalle Roland Eils Albrecht Stenzinger Wilko Weichert Hanno Glimm Stefan Gröschel Hans-Georg Kopp Georg Omlor Burkhard Lehner Sebastian Bauer Simon Schimmack Alexis Ulrich Gunhild Mechtersheimer Karsten Rippe Benedikt Brors Barbara Hutter Marcus Renner Peter Hohenberger Claudia Scholl Stefan Fröhling Integrative genomic and transcriptomic analysis of leiomyosarcoma
description	The molecular genetic landscape of leiomyosarcoma (LMS) is largely unknown. Here, the authors identify frequent DNA copy number alterations, whole-genome duplication, TP53 and RB1 inactivation, alternative telomere lengthening, and genomic imprints of defective DNA repair via homologous recombination as a potential therapeutic target in LMS patients.
format	article
author	Priya Chudasama Sadaf S. Mughal Mathijs A. Sanders Daniel Hübschmann Inn Chung Katharina I. Deeg Siao-Han Wong Sophie Rabe Mario Hlevnjak Marc Zapatka Aurélie Ernst Kortine Kleinheinz Matthias Schlesner Lina Sieverling Barbara Klink Evelin Schröck Remco M. Hoogenboezem Bernd Kasper Christoph E. Heilig Gerlinde Egerer Stephan Wolf Christof von Kalle Roland Eils Albrecht Stenzinger Wilko Weichert Hanno Glimm Stefan Gröschel Hans-Georg Kopp Georg Omlor Burkhard Lehner Sebastian Bauer Simon Schimmack Alexis Ulrich Gunhild Mechtersheimer Karsten Rippe Benedikt Brors Barbara Hutter Marcus Renner Peter Hohenberger Claudia Scholl Stefan Fröhling
author_facet	Priya Chudasama Sadaf S. Mughal Mathijs A. Sanders Daniel Hübschmann Inn Chung Katharina I. Deeg Siao-Han Wong Sophie Rabe Mario Hlevnjak Marc Zapatka Aurélie Ernst Kortine Kleinheinz Matthias Schlesner Lina Sieverling Barbara Klink Evelin Schröck Remco M. Hoogenboezem Bernd Kasper Christoph E. Heilig Gerlinde Egerer Stephan Wolf Christof von Kalle Roland Eils Albrecht Stenzinger Wilko Weichert Hanno Glimm Stefan Gröschel Hans-Georg Kopp Georg Omlor Burkhard Lehner Sebastian Bauer Simon Schimmack Alexis Ulrich Gunhild Mechtersheimer Karsten Rippe Benedikt Brors Barbara Hutter Marcus Renner Peter Hohenberger Claudia Scholl Stefan Fröhling
author_sort	Priya Chudasama
title	Integrative genomic and transcriptomic analysis of leiomyosarcoma
title_short	Integrative genomic and transcriptomic analysis of leiomyosarcoma
title_full	Integrative genomic and transcriptomic analysis of leiomyosarcoma
title_fullStr	Integrative genomic and transcriptomic analysis of leiomyosarcoma
title_full_unstemmed	Integrative genomic and transcriptomic analysis of leiomyosarcoma
title_sort	integrative genomic and transcriptomic analysis of leiomyosarcoma
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/d4d8c497353f4a34a7f3673b1d82cb28
work_keys_str_mv	AT priyachudasama integrativegenomicandtranscriptomicanalysisofleiomyosarcoma AT sadafsmughal integrativegenomicandtranscriptomicanalysisofleiomyosarcoma AT mathijsasanders integrativegenomicandtranscriptomicanalysisofleiomyosarcoma AT danielhubschmann integrativegenomicandtranscriptomicanalysisofleiomyosarcoma AT innchung integrativegenomicandtranscriptomicanalysisofleiomyosarcoma AT katharinaideeg integrativegenomicandtranscriptomicanalysisofleiomyosarcoma AT siaohanwong integrativegenomicandtranscriptomicanalysisofleiomyosarcoma AT sophierabe integrativegenomicandtranscriptomicanalysisofleiomyosarcoma AT mariohlevnjak integrativegenomicandtranscriptomicanalysisofleiomyosarcoma AT marczapatka integrativegenomicandtranscriptomicanalysisofleiomyosarcoma AT aurelieernst integrativegenomicandtranscriptomicanalysisofleiomyosarcoma AT kortinekleinheinz integrativegenomicandtranscriptomicanalysisofleiomyosarcoma AT matthiasschlesner integrativegenomicandtranscriptomicanalysisofleiomyosarcoma AT linasieverling integrativegenomicandtranscriptomicanalysisofleiomyosarcoma AT barbaraklink integrativegenomicandtranscriptomicanalysisofleiomyosarcoma AT evelinschrock integrativegenomicandtranscriptomicanalysisofleiomyosarcoma AT remcomhoogenboezem integrativegenomicandtranscriptomicanalysisofleiomyosarcoma AT berndkasper integrativegenomicandtranscriptomicanalysisofleiomyosarcoma AT christopheheilig integrativegenomicandtranscriptomicanalysisofleiomyosarcoma AT gerlindeegerer integrativegenomicandtranscriptomicanalysisofleiomyosarcoma AT stephanwolf integrativegenomicandtranscriptomicanalysisofleiomyosarcoma AT christofvonkalle integrativegenomicandtranscriptomicanalysisofleiomyosarcoma AT rolandeils integrativegenomicandtranscriptomicanalysisofleiomyosarcoma AT albrechtstenzinger integrativegenomicandtranscriptomicanalysisofleiomyosarcoma AT wilkoweichert integrativegenomicandtranscriptomicanalysisofleiomyosarcoma AT hannoglimm integrativegenomicandtranscriptomicanalysisofleiomyosarcoma AT stefangroschel integrativegenomicandtranscriptomicanalysisofleiomyosarcoma AT hansgeorgkopp integrativegenomicandtranscriptomicanalysisofleiomyosarcoma AT georgomlor integrativegenomicandtranscriptomicanalysisofleiomyosarcoma AT burkhardlehner integrativegenomicandtranscriptomicanalysisofleiomyosarcoma AT sebastianbauer integrativegenomicandtranscriptomicanalysisofleiomyosarcoma AT simonschimmack integrativegenomicandtranscriptomicanalysisofleiomyosarcoma AT alexisulrich integrativegenomicandtranscriptomicanalysisofleiomyosarcoma AT gunhildmechtersheimer integrativegenomicandtranscriptomicanalysisofleiomyosarcoma AT karstenrippe integrativegenomicandtranscriptomicanalysisofleiomyosarcoma AT benediktbrors integrativegenomicandtranscriptomicanalysisofleiomyosarcoma AT barbarahutter integrativegenomicandtranscriptomicanalysisofleiomyosarcoma AT marcusrenner integrativegenomicandtranscriptomicanalysisofleiomyosarcoma AT peterhohenberger integrativegenomicandtranscriptomicanalysisofleiomyosarcoma AT claudiascholl integrativegenomicandtranscriptomicanalysisofleiomyosarcoma AT stefanfrohling integrativegenomicandtranscriptomicanalysisofleiomyosarcoma
_version_	1718390445499744256

Integrative genomic and transcriptomic analysis of leiomyosarcoma

Ejemplares similares