Polycomb protein SCML2 regulates the cell cycle by binding and modulating CDK/CYCLIN/p21 complexes.

Polycomb group (PcG) proteins are transcriptional repressors of genes involved in development and differentiation, and also maintain repression of key genes involved in the cell cycle, indirectly regulating cell proliferation. The human SCML2 gene, a mammalian homologue of the Drosophila PcG protein...

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Autores principales: Emilio Lecona, Luis Alejandro Rojas, Roberto Bonasio, Andrew Johnston, Oscar Fernández-Capetillo, Danny Reinberg
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2013
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Acceso en línea:https://doaj.org/article/d4ddbaaa48fc4b02b8abd870469d19f8
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