Polycomb protein SCML2 regulates the cell cycle by binding and modulating CDK/CYCLIN/p21 complexes.
Polycomb group (PcG) proteins are transcriptional repressors of genes involved in development and differentiation, and also maintain repression of key genes involved in the cell cycle, indirectly regulating cell proliferation. The human SCML2 gene, a mammalian homologue of the Drosophila PcG protein...
Saved in:
Main Authors: | Emilio Lecona, Luis Alejandro Rojas, Roberto Bonasio, Andrew Johnston, Oscar Fernández-Capetillo, Danny Reinberg |
---|---|
Format: | article |
Language: | EN |
Published: |
Public Library of Science (PLoS)
2013
|
Subjects: | |
Online Access: | https://doaj.org/article/d4ddbaaa48fc4b02b8abd870469d19f8 |
Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
Similar Items
-
Clinical CDK4/6 inhibitors induce selective and immediate dissociation of p21 from cyclin D-CDK4 to inhibit CDK2
by: Lindsey R. Pack, et al.
Published: (2021) -
AMPK-dependent activation of the Cyclin Y/CDK16 complex controls autophagy
by: Marc Dohmen, et al.
Published: (2020) -
Dynamic anticipation by Cdk2/Cyclin A-bound p27 mediates signal integration in cell cycle regulation
by: Maksym Tsytlonok, et al.
Published: (2019) -
Nucleophosmin phosphorylation by v-cyclin-CDK6 controls KSHV latency.
by: Grzegorz Sarek, et al.
Published: (2010) -
Cyclin E/CDK2: DNA Replication, Replication Stress and Genomic Instability
by: Rafaela Fagundes, et al.
Published: (2021)