Traceless native chemical ligation of lipid-modified peptide surfactants by mixed micelle formation

Sequestration of reactants in lipid vesicles is a strategy prevalent in biological systems to raise the rate and specificity of chemical reactions. Here, the authors show that micelle-assisted reactions facilitate native chemical ligation between a peptide-thioester and a Cys-peptide modified by a l...

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Autores principales: Shuaijiang Jin, Roberto J. Brea, Andrew K. Rudd, Stuart P. Moon, Matthew R. Pratt, Neal K. Devaraj
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2020
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Acceso en línea:https://doaj.org/article/d523faaf6776431fa7a2b80e8cddfeb5
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