Traceless native chemical ligation of lipid-modified peptide surfactants by mixed micelle formation

Sequestration of reactants in lipid vesicles is a strategy prevalent in biological systems to raise the rate and specificity of chemical reactions. Here, the authors show that micelle-assisted reactions facilitate native chemical ligation between a peptide-thioester and a Cys-peptide modified by a l...

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Autores principales:	Shuaijiang Jin, Roberto J. Brea, Andrew K. Rudd, Stuart P. Moon, Matthew R. Pratt, Neal K. Devaraj
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/d523faaf6776431fa7a2b80e8cddfeb5
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spelling	oai:doaj.org-article:d523faaf6776431fa7a2b80e8cddfeb52021-12-02T15:02:47ZTraceless native chemical ligation of lipid-modified peptide surfactants by mixed micelle formation10.1038/s41467-020-16595-w2041-1723https://doaj.org/article/d523faaf6776431fa7a2b80e8cddfeb52020-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-16595-whttps://doaj.org/toc/2041-1723Sequestration of reactants in lipid vesicles is a strategy prevalent in biological systems to raise the rate and specificity of chemical reactions. Here, the authors show that micelle-assisted reactions facilitate native chemical ligation between a peptide-thioester and a Cys-peptide modified by a lipid-like moiety.Shuaijiang JinRoberto J. BreaAndrew K. RuddStuart P. MoonMatthew R. PrattNeal K. DevarajNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-10 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Shuaijiang Jin Roberto J. Brea Andrew K. Rudd Stuart P. Moon Matthew R. Pratt Neal K. Devaraj Traceless native chemical ligation of lipid-modified peptide surfactants by mixed micelle formation
description	Sequestration of reactants in lipid vesicles is a strategy prevalent in biological systems to raise the rate and specificity of chemical reactions. Here, the authors show that micelle-assisted reactions facilitate native chemical ligation between a peptide-thioester and a Cys-peptide modified by a lipid-like moiety.
format	article
author	Shuaijiang Jin Roberto J. Brea Andrew K. Rudd Stuart P. Moon Matthew R. Pratt Neal K. Devaraj
author_facet	Shuaijiang Jin Roberto J. Brea Andrew K. Rudd Stuart P. Moon Matthew R. Pratt Neal K. Devaraj
author_sort	Shuaijiang Jin
title	Traceless native chemical ligation of lipid-modified peptide surfactants by mixed micelle formation
title_short	Traceless native chemical ligation of lipid-modified peptide surfactants by mixed micelle formation
title_full	Traceless native chemical ligation of lipid-modified peptide surfactants by mixed micelle formation
title_fullStr	Traceless native chemical ligation of lipid-modified peptide surfactants by mixed micelle formation
title_full_unstemmed	Traceless native chemical ligation of lipid-modified peptide surfactants by mixed micelle formation
title_sort	traceless native chemical ligation of lipid-modified peptide surfactants by mixed micelle formation
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/d523faaf6776431fa7a2b80e8cddfeb5
work_keys_str_mv	AT shuaijiangjin tracelessnativechemicalligationoflipidmodifiedpeptidesurfactantsbymixedmicelleformation AT robertojbrea tracelessnativechemicalligationoflipidmodifiedpeptidesurfactantsbymixedmicelleformation AT andrewkrudd tracelessnativechemicalligationoflipidmodifiedpeptidesurfactantsbymixedmicelleformation AT stuartpmoon tracelessnativechemicalligationoflipidmodifiedpeptidesurfactantsbymixedmicelleformation AT matthewrpratt tracelessnativechemicalligationoflipidmodifiedpeptidesurfactantsbymixedmicelleformation AT nealkdevaraj tracelessnativechemicalligationoflipidmodifiedpeptidesurfactantsbymixedmicelleformation
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Traceless native chemical ligation of lipid-modified peptide surfactants by mixed micelle formation

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