Reversible histone glycation is associated with disease-related changes in chromatin architecture

Proteins continuously undergo non-enzymatic modifications such as glycation, which accumulate under physiological conditions but can be enhanced in disease. Here the authors characterise histone glycation, provide evidence that it affects chromatin, particularly in breast cancer, and identify DJ-1 a...

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Auteurs principaux: Qingfei Zheng, Nathaniel D. Omans, Rachel Leicher, Adewola Osunsade, Albert S. Agustinus, Efrat Finkin-Groner, Hannah D’Ambrosio, Bo Liu, Sarat Chandarlapaty, Shixin Liu, Yael David
Format: article
Langue:EN
Publié: Nature Portfolio 2019
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Accès en ligne:https://doaj.org/article/d549df8147a043739d0eb71b8d597555
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