Reversible histone glycation is associated with disease-related changes in chromatin architecture

Proteins continuously undergo non-enzymatic modifications such as glycation, which accumulate under physiological conditions but can be enhanced in disease. Here the authors characterise histone glycation, provide evidence that it affects chromatin, particularly in breast cancer, and identify DJ-1 a...

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Autores principales:	Qingfei Zheng, Nathaniel D. Omans, Rachel Leicher, Adewola Osunsade, Albert S. Agustinus, Efrat Finkin-Groner, Hannah D’Ambrosio, Bo Liu, Sarat Chandarlapaty, Shixin Liu, Yael David
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/d549df8147a043739d0eb71b8d597555
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spelling	oai:doaj.org-article:d549df8147a043739d0eb71b8d5975552021-12-02T17:02:09ZReversible histone glycation is associated with disease-related changes in chromatin architecture10.1038/s41467-019-09192-z2041-1723https://doaj.org/article/d549df8147a043739d0eb71b8d5975552019-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-09192-zhttps://doaj.org/toc/2041-1723Proteins continuously undergo non-enzymatic modifications such as glycation, which accumulate under physiological conditions but can be enhanced in disease. Here the authors characterise histone glycation, provide evidence that it affects chromatin, particularly in breast cancer, and identify DJ-1 as a deglycase.Qingfei ZhengNathaniel D. OmansRachel LeicherAdewola OsunsadeAlbert S. AgustinusEfrat Finkin-GronerHannah D’AmbrosioBo LiuSarat ChandarlapatyShixin LiuYael DavidNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-12 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Qingfei Zheng Nathaniel D. Omans Rachel Leicher Adewola Osunsade Albert S. Agustinus Efrat Finkin-Groner Hannah D’Ambrosio Bo Liu Sarat Chandarlapaty Shixin Liu Yael David Reversible histone glycation is associated with disease-related changes in chromatin architecture
description	Proteins continuously undergo non-enzymatic modifications such as glycation, which accumulate under physiological conditions but can be enhanced in disease. Here the authors characterise histone glycation, provide evidence that it affects chromatin, particularly in breast cancer, and identify DJ-1 as a deglycase.
format	article
author	Qingfei Zheng Nathaniel D. Omans Rachel Leicher Adewola Osunsade Albert S. Agustinus Efrat Finkin-Groner Hannah D’Ambrosio Bo Liu Sarat Chandarlapaty Shixin Liu Yael David
author_facet	Qingfei Zheng Nathaniel D. Omans Rachel Leicher Adewola Osunsade Albert S. Agustinus Efrat Finkin-Groner Hannah D’Ambrosio Bo Liu Sarat Chandarlapaty Shixin Liu Yael David
author_sort	Qingfei Zheng
title	Reversible histone glycation is associated with disease-related changes in chromatin architecture
title_short	Reversible histone glycation is associated with disease-related changes in chromatin architecture
title_full	Reversible histone glycation is associated with disease-related changes in chromatin architecture
title_fullStr	Reversible histone glycation is associated with disease-related changes in chromatin architecture
title_full_unstemmed	Reversible histone glycation is associated with disease-related changes in chromatin architecture
title_sort	reversible histone glycation is associated with disease-related changes in chromatin architecture
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/d549df8147a043739d0eb71b8d597555
work_keys_str_mv	AT qingfeizheng reversiblehistoneglycationisassociatedwithdiseaserelatedchangesinchromatinarchitecture AT nathanieldomans reversiblehistoneglycationisassociatedwithdiseaserelatedchangesinchromatinarchitecture AT rachelleicher reversiblehistoneglycationisassociatedwithdiseaserelatedchangesinchromatinarchitecture AT adewolaosunsade reversiblehistoneglycationisassociatedwithdiseaserelatedchangesinchromatinarchitecture AT albertsagustinus reversiblehistoneglycationisassociatedwithdiseaserelatedchangesinchromatinarchitecture AT efratfinkingroner reversiblehistoneglycationisassociatedwithdiseaserelatedchangesinchromatinarchitecture AT hannahdambrosio reversiblehistoneglycationisassociatedwithdiseaserelatedchangesinchromatinarchitecture AT boliu reversiblehistoneglycationisassociatedwithdiseaserelatedchangesinchromatinarchitecture AT saratchandarlapaty reversiblehistoneglycationisassociatedwithdiseaserelatedchangesinchromatinarchitecture AT shixinliu reversiblehistoneglycationisassociatedwithdiseaserelatedchangesinchromatinarchitecture AT yaeldavid reversiblehistoneglycationisassociatedwithdiseaserelatedchangesinchromatinarchitecture
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Reversible histone glycation is associated with disease-related changes in chromatin architecture

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