Dissociation of disease onset, progression and sex differences from androgen receptor levels in a mouse model of amyotrophic lateral sclerosis

Abstract Amyotrophic lateral sclerosis (ALS) is an adult-onset neurodegenerative disorder caused by loss of motor neurons. ALS incidence is skewed towards males with typically earlier age of onset and limb site of onset. The androgen receptor (AR) is the major mediator of androgen effects in the bod...

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Autores principales: Doris Tomas, Victoria M. McLeod, Mathew D. F. Chiam, Nayomi Wanniarachchillage, Wah C. Boon, Bradley J. Turner
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/d568045e10774a8ab9a42419d98dbd32
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