Quantification of the overall contribution of gene-environment interaction for obesity-related traits

Most gene-by-environment interaction methods rely on the availability of the interacting environment. Here, the authors propose a robust maximum likelihood method for estimating the overall statistical interaction between a genetic risk score for a continuous outcome and all environmental variables.

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Auteurs principaux: Jonathan Sulc, Ninon Mounier, Felix Günther, Thomas Winkler, Andrew R. Wood, Timothy M. Frayling, Iris M. Heid, Matthew R. Robinson, Zoltán Kutalik
Format: article
Langue:EN
Publié: Nature Portfolio 2020
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Accès en ligne:https://doaj.org/article/d57fd22b9d4044d6822ee669df08a385
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