Gene expression dysregulation domains are not a specific feature of Down syndrome

Gene expression dysregulation domains are not a specific feature of Down syndrome

Gene expression dysregulation domains (GEDDs) have been reported in Down syndrome (DS) cells, where changes in gene expression are clustered. Here the authors find that, while GEDDs are present in DS cells and in the Dp1Tyb mouse model of DS, GEDDs do not depend on the DS genotype and occur whenever...

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Autores principales: Helena Ahlfors, Nneka Anyanwu, Edvinas Pakanavicius, Natalia Dinischiotu, Eva Lana-Elola, Sheona Watson-Scales, Justin Tosh, Frances Wiseman, James Briscoe, Karen Page, Elizabeth M. C. Fisher, Victor L. J. Tybulewicz
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2019
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Acceso en línea:https://doaj.org/article/d58c59e260be485db688012547887273
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spelling oai:doaj.org-article:d58c59e260be485db6880125478872732021-12-02T14:39:00ZGene expression dysregulation domains are not a specific feature of Down syndrome10.1038/s41467-019-10129-92041-1723https://doaj.org/article/d58c59e260be485db6880125478872732019-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-10129-9https://doaj.org/toc/2041-1723Gene expression dysregulation domains (GEDDs) have been reported in Down syndrome (DS) cells, where changes in gene expression are clustered. Here the authors find that, while GEDDs are present in DS cells and in the Dp1Tyb mouse model of DS, GEDDs do not depend on the DS genotype and occur whenever gene expression changes, suggesting they result from the clustering of co-regulated genes as a function of mammalian genome organisation.Helena AhlforsNneka AnyanwuEdvinas PakanaviciusNatalia DinischiotuEva Lana-ElolaSheona Watson-ScalesJustin ToshFrances WisemanJames BriscoeKaren PageElizabeth M. C. FisherVictor L. J. TybulewiczNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-12 (2019)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Helena Ahlfors
Nneka Anyanwu
Edvinas Pakanavicius
Natalia Dinischiotu
Eva Lana-Elola
Sheona Watson-Scales
Justin Tosh
Frances Wiseman
James Briscoe
Karen Page
Elizabeth M. C. Fisher
Victor L. J. Tybulewicz
Gene expression dysregulation domains are not a specific feature of Down syndrome
description Gene expression dysregulation domains (GEDDs) have been reported in Down syndrome (DS) cells, where changes in gene expression are clustered. Here the authors find that, while GEDDs are present in DS cells and in the Dp1Tyb mouse model of DS, GEDDs do not depend on the DS genotype and occur whenever gene expression changes, suggesting they result from the clustering of co-regulated genes as a function of mammalian genome organisation.
format article
author Helena Ahlfors
Nneka Anyanwu
Edvinas Pakanavicius
Natalia Dinischiotu
Eva Lana-Elola
Sheona Watson-Scales
Justin Tosh
Frances Wiseman
James Briscoe
Karen Page
Elizabeth M. C. Fisher
Victor L. J. Tybulewicz
author_facet Helena Ahlfors
Nneka Anyanwu
Edvinas Pakanavicius
Natalia Dinischiotu
Eva Lana-Elola
Sheona Watson-Scales
Justin Tosh
Frances Wiseman
James Briscoe
Karen Page
Elizabeth M. C. Fisher
Victor L. J. Tybulewicz
author_sort Helena Ahlfors
title Gene expression dysregulation domains are not a specific feature of Down syndrome
title_short Gene expression dysregulation domains are not a specific feature of Down syndrome
title_full Gene expression dysregulation domains are not a specific feature of Down syndrome
title_fullStr Gene expression dysregulation domains are not a specific feature of Down syndrome
title_full_unstemmed Gene expression dysregulation domains are not a specific feature of Down syndrome
title_sort gene expression dysregulation domains are not a specific feature of down syndrome
publisher Nature Portfolio
publishDate 2019
url https://doaj.org/article/d58c59e260be485db688012547887273
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