Chemogenetic generation of hydrogen peroxide in the heart induces severe cardiac dysfunction

Excessive production of reactive oxygen species (ROS) is associated with cardiac dysfunction, but the causal role of ROS remains poorly understood. Here the authors use an in vivo chemogenetic approach to develop a heart failure model in which generation of hydrogen peroxide in the heart leads to sy...

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Bibliographic Details
Main Authors: Benjamin Steinhorn, Andrea Sorrentino, Sachin Badole, Yulia Bogdanova, Vsevolod Belousov, Thomas Michel
Format: article
Language:EN
Published: Nature Portfolio 2018
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Online Access:https://doaj.org/article/d59353f07e174fe28d55d7572a9f3394
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