Chemogenetic generation of hydrogen peroxide in the heart induces severe cardiac dysfunction
Excessive production of reactive oxygen species (ROS) is associated with cardiac dysfunction, but the causal role of ROS remains poorly understood. Here the authors use an in vivo chemogenetic approach to develop a heart failure model in which generation of hydrogen peroxide in the heart leads to sy...
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2018
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oai:doaj.org-article:d59353f07e174fe28d55d7572a9f33942021-12-02T15:33:41ZChemogenetic generation of hydrogen peroxide in the heart induces severe cardiac dysfunction10.1038/s41467-018-06533-22041-1723https://doaj.org/article/d59353f07e174fe28d55d7572a9f33942018-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-06533-2https://doaj.org/toc/2041-1723Excessive production of reactive oxygen species (ROS) is associated with cardiac dysfunction, but the causal role of ROS remains poorly understood. Here the authors use an in vivo chemogenetic approach to develop a heart failure model in which generation of hydrogen peroxide in the heart leads to systolic heart failure without fibrotic remodeling.Benjamin SteinhornAndrea SorrentinoSachin BadoleYulia BogdanovaVsevolod BelousovThomas MichelNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-10 (2018) |
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Science Q Benjamin Steinhorn Andrea Sorrentino Sachin Badole Yulia Bogdanova Vsevolod Belousov Thomas Michel Chemogenetic generation of hydrogen peroxide in the heart induces severe cardiac dysfunction |
description |
Excessive production of reactive oxygen species (ROS) is associated with cardiac dysfunction, but the causal role of ROS remains poorly understood. Here the authors use an in vivo chemogenetic approach to develop a heart failure model in which generation of hydrogen peroxide in the heart leads to systolic heart failure without fibrotic remodeling. |
format |
article |
author |
Benjamin Steinhorn Andrea Sorrentino Sachin Badole Yulia Bogdanova Vsevolod Belousov Thomas Michel |
author_facet |
Benjamin Steinhorn Andrea Sorrentino Sachin Badole Yulia Bogdanova Vsevolod Belousov Thomas Michel |
author_sort |
Benjamin Steinhorn |
title |
Chemogenetic generation of hydrogen peroxide in the heart induces severe cardiac dysfunction |
title_short |
Chemogenetic generation of hydrogen peroxide in the heart induces severe cardiac dysfunction |
title_full |
Chemogenetic generation of hydrogen peroxide in the heart induces severe cardiac dysfunction |
title_fullStr |
Chemogenetic generation of hydrogen peroxide in the heart induces severe cardiac dysfunction |
title_full_unstemmed |
Chemogenetic generation of hydrogen peroxide in the heart induces severe cardiac dysfunction |
title_sort |
chemogenetic generation of hydrogen peroxide in the heart induces severe cardiac dysfunction |
publisher |
Nature Portfolio |
publishDate |
2018 |
url |
https://doaj.org/article/d59353f07e174fe28d55d7572a9f3394 |
work_keys_str_mv |
AT benjaminsteinhorn chemogeneticgenerationofhydrogenperoxideintheheartinducesseverecardiacdysfunction AT andreasorrentino chemogeneticgenerationofhydrogenperoxideintheheartinducesseverecardiacdysfunction AT sachinbadole chemogeneticgenerationofhydrogenperoxideintheheartinducesseverecardiacdysfunction AT yuliabogdanova chemogeneticgenerationofhydrogenperoxideintheheartinducesseverecardiacdysfunction AT vsevolodbelousov chemogeneticgenerationofhydrogenperoxideintheheartinducesseverecardiacdysfunction AT thomasmichel chemogeneticgenerationofhydrogenperoxideintheheartinducesseverecardiacdysfunction |
_version_ |
1718387052879282176 |