Chemogenetic generation of hydrogen peroxide in the heart induces severe cardiac dysfunction

Excessive production of reactive oxygen species (ROS) is associated with cardiac dysfunction, but the causal role of ROS remains poorly understood. Here the authors use an in vivo chemogenetic approach to develop a heart failure model in which generation of hydrogen peroxide in the heart leads to sy...

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Auteurs principaux:	Benjamin Steinhorn, Andrea Sorrentino, Sachin Badole, Yulia Bogdanova, Vsevolod Belousov, Thomas Michel
Format:	article
Langue:	EN
Publié:	Nature Portfolio 2018
Sujets:	Science Q
Accès en ligne:	https://doaj.org/article/d59353f07e174fe28d55d7572a9f3394
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spelling	oai:doaj.org-article:d59353f07e174fe28d55d7572a9f33942021-12-02T15:33:41ZChemogenetic generation of hydrogen peroxide in the heart induces severe cardiac dysfunction10.1038/s41467-018-06533-22041-1723https://doaj.org/article/d59353f07e174fe28d55d7572a9f33942018-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-06533-2https://doaj.org/toc/2041-1723Excessive production of reactive oxygen species (ROS) is associated with cardiac dysfunction, but the causal role of ROS remains poorly understood. Here the authors use an in vivo chemogenetic approach to develop a heart failure model in which generation of hydrogen peroxide in the heart leads to systolic heart failure without fibrotic remodeling.Benjamin SteinhornAndrea SorrentinoSachin BadoleYulia BogdanovaVsevolod BelousovThomas MichelNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-10 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Benjamin Steinhorn Andrea Sorrentino Sachin Badole Yulia Bogdanova Vsevolod Belousov Thomas Michel Chemogenetic generation of hydrogen peroxide in the heart induces severe cardiac dysfunction
description	Excessive production of reactive oxygen species (ROS) is associated with cardiac dysfunction, but the causal role of ROS remains poorly understood. Here the authors use an in vivo chemogenetic approach to develop a heart failure model in which generation of hydrogen peroxide in the heart leads to systolic heart failure without fibrotic remodeling.
format	article
author	Benjamin Steinhorn Andrea Sorrentino Sachin Badole Yulia Bogdanova Vsevolod Belousov Thomas Michel
author_facet	Benjamin Steinhorn Andrea Sorrentino Sachin Badole Yulia Bogdanova Vsevolod Belousov Thomas Michel
author_sort	Benjamin Steinhorn
title	Chemogenetic generation of hydrogen peroxide in the heart induces severe cardiac dysfunction
title_short	Chemogenetic generation of hydrogen peroxide in the heart induces severe cardiac dysfunction
title_full	Chemogenetic generation of hydrogen peroxide in the heart induces severe cardiac dysfunction
title_fullStr	Chemogenetic generation of hydrogen peroxide in the heart induces severe cardiac dysfunction
title_full_unstemmed	Chemogenetic generation of hydrogen peroxide in the heart induces severe cardiac dysfunction
title_sort	chemogenetic generation of hydrogen peroxide in the heart induces severe cardiac dysfunction
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/d59353f07e174fe28d55d7572a9f3394
work_keys_str_mv	AT benjaminsteinhorn chemogeneticgenerationofhydrogenperoxideintheheartinducesseverecardiacdysfunction AT andreasorrentino chemogeneticgenerationofhydrogenperoxideintheheartinducesseverecardiacdysfunction AT sachinbadole chemogeneticgenerationofhydrogenperoxideintheheartinducesseverecardiacdysfunction AT yuliabogdanova chemogeneticgenerationofhydrogenperoxideintheheartinducesseverecardiacdysfunction AT vsevolodbelousov chemogeneticgenerationofhydrogenperoxideintheheartinducesseverecardiacdysfunction AT thomasmichel chemogeneticgenerationofhydrogenperoxideintheheartinducesseverecardiacdysfunction
_version_	1718387052879282176

Chemogenetic generation of hydrogen peroxide in the heart induces severe cardiac dysfunction

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