HSP90 inhibitors stimulate DNAJB4 protein expression through a mechanism involving N 6-methyladenosine

Cells respond to heat shock with transcriptional and translational adaptations but how HSP90 inhibition alters the heat shock proteome is largely unclear. Here, the authors analyze proteome changes upon HSP90 inhibition and show that an m6A-mediated mechanism contributes to the heat shock-induced up...

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Autores principales: Weili Miao, Lin Li, Yonghui Zhao, Xiaoxia Dai, Xuemei Chen, Yinsheng Wang
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2019
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Acceso en línea:https://doaj.org/article/d5b169dda19b4114b793919586071e34
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