HSP90 inhibitors stimulate DNAJB4 protein expression through a mechanism involving N 6-methyladenosine

HSP90 inhibitors stimulate DNAJB4 protein expression through a mechanism involving N 6-methyladenosine

Cells respond to heat shock with transcriptional and translational adaptations but how HSP90 inhibition alters the heat shock proteome is largely unclear. Here, the authors analyze proteome changes upon HSP90 inhibition and show that an m6A-mediated mechanism contributes to the heat shock-induced up...

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Autores principales: Weili Miao, Lin Li, Yonghui Zhao, Xiaoxia Dai, Xuemei Chen, Yinsheng Wang
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2019
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Acceso en línea:https://doaj.org/article/d5b169dda19b4114b793919586071e34
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spelling oai:doaj.org-article:d5b169dda19b4114b793919586071e342021-12-02T14:39:18ZHSP90 inhibitors stimulate DNAJB4 protein expression through a mechanism involving N 6-methyladenosine10.1038/s41467-019-11552-82041-1723https://doaj.org/article/d5b169dda19b4114b793919586071e342019-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-11552-8https://doaj.org/toc/2041-1723Cells respond to heat shock with transcriptional and translational adaptations but how HSP90 inhibition alters the heat shock proteome is largely unclear. Here, the authors analyze proteome changes upon HSP90 inhibition and show that an m6A-mediated mechanism contributes to the heat shock-induced upregulation of DNAJB4.Weili MiaoLin LiYonghui ZhaoXiaoxia DaiXuemei ChenYinsheng WangNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-12 (2019)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Weili Miao
Lin Li
Yonghui Zhao
Xiaoxia Dai
Xuemei Chen
Yinsheng Wang
HSP90 inhibitors stimulate DNAJB4 protein expression through a mechanism involving N 6-methyladenosine
description Cells respond to heat shock with transcriptional and translational adaptations but how HSP90 inhibition alters the heat shock proteome is largely unclear. Here, the authors analyze proteome changes upon HSP90 inhibition and show that an m6A-mediated mechanism contributes to the heat shock-induced upregulation of DNAJB4.
format article
author Weili Miao
Lin Li
Yonghui Zhao
Xiaoxia Dai
Xuemei Chen
Yinsheng Wang
author_facet Weili Miao
Lin Li
Yonghui Zhao
Xiaoxia Dai
Xuemei Chen
Yinsheng Wang
author_sort Weili Miao
title HSP90 inhibitors stimulate DNAJB4 protein expression through a mechanism involving N 6-methyladenosine
title_short HSP90 inhibitors stimulate DNAJB4 protein expression through a mechanism involving N 6-methyladenosine
title_full HSP90 inhibitors stimulate DNAJB4 protein expression through a mechanism involving N 6-methyladenosine
title_fullStr HSP90 inhibitors stimulate DNAJB4 protein expression through a mechanism involving N 6-methyladenosine
title_full_unstemmed HSP90 inhibitors stimulate DNAJB4 protein expression through a mechanism involving N 6-methyladenosine
title_sort hsp90 inhibitors stimulate dnajb4 protein expression through a mechanism involving n 6-methyladenosine
publisher Nature Portfolio
publishDate 2019
url https://doaj.org/article/d5b169dda19b4114b793919586071e34
work_keys_str_mv AT weilimiao hsp90inhibitorsstimulatednajb4proteinexpressionthroughamechanisminvolvingn6methyladenosine
AT linli hsp90inhibitorsstimulatednajb4proteinexpressionthroughamechanisminvolvingn6methyladenosine
AT yonghuizhao hsp90inhibitorsstimulatednajb4proteinexpressionthroughamechanisminvolvingn6methyladenosine
AT xiaoxiadai hsp90inhibitorsstimulatednajb4proteinexpressionthroughamechanisminvolvingn6methyladenosine
AT xuemeichen hsp90inhibitorsstimulatednajb4proteinexpressionthroughamechanisminvolvingn6methyladenosine
AT yinshengwang hsp90inhibitorsstimulatednajb4proteinexpressionthroughamechanisminvolvingn6methyladenosine
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