Random-PE: an efficient integration of random sequences into mammalian genome by prime editing

Abstract Prime editing (PE) enables efficiently targeted introduction of multiple types of small-sized genetic change without requiring double-strand breaks or donor templates. Here we designed a simple strategy to introduce random DNA sequences into targeted genomic loci by prime editing, which we...

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Autores principales: Yaoge Jiao, Lifang Zhou, Rui Tao, Yanhong Wang, Yun Hu, Lurong Jiang, Li Li, Shaohua Yao
Formato: article
Lenguaje:EN
Publicado: Springer 2021
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R
Acceso en línea:https://doaj.org/article/d5b86a6e19364c48be43fc0880890585
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