PCM1 is necessary for focal ciliary integrity and is a candidate for severe schizophrenia

PCM1 is necessary for focal ciliary integrity and is a candidate for severe schizophrenia

The role of ciliary/centriolar components in the postnatal brain is unclear. Here, the authors show via ablation of Pcm1 in mice that degenerative ciliary/centriolar phenotypes induce neuroanatomical and behavioral changes. Sequencing of PCM1 in human cohorts and zebrafish in vivo complementation su...

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Auteurs principaux: Tanner O. Monroe, Melanie E. Garrett, Maria Kousi, Ramona M. Rodriguiz, Sungjin Moon, Yushi Bai, Steven C. Brodar, Karen L. Soldano, Jeremiah Savage, Thomas F. Hansen, Donna M. Muzny, Richard A. Gibbs, Lawrence Barak, Patrick F. Sullivan, Allison E. Ashley-Koch, Akira Sawa, William C. Wetsel, Thomas Werge, Nicholas Katsanis
Format: article
Langue:EN
Publié: Nature Portfolio 2020
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Science
Q
Accès en ligne:https://doaj.org/article/d5f60ef175b64f618a0d4c6e80cba746
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