Astrocyte-specific overexpression of Nrf2 protects against optic tract damage and behavioural alterations in a mouse model of cerebral hypoperfusion

Abstract Mouse models have shown that cerebral hypoperfusion causes white matter disruption and memory impairment relevant to the study of vascular cognitive impairment and dementia. The associated mechanisms include inflammation and oxidative stress are proposed to drive disruption of myelinated ax...

Full description

Saved in:
Bibliographic Details
Main Authors: Emma Sigfridsson, Martina Marangoni, Jeffrey A. Johnson, Giles E. Hardingham, Jill H. Fowler, Karen Horsburgh
Format: article
Language:EN
Published: Nature Portfolio 2018
Subjects:
R
Q
Online Access:https://doaj.org/article/d600fb320b054084b56284ae738c586b
Tags: Add Tag
No Tags, Be the first to tag this record!