Evaluation of animal genetic and physiological factors that affect the prevalence of Escherichia coli O157 in cattle.

Controlling the prevalence of Escherichia coli O157 in cattle at the pre-harvest level is critical to reduce outbreaks of this pathogen in humans. Multilayers of factors including the environmental and bacterial factors modulate the colonization and persistence of E. coli O157 in cattle that serve a...

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Autores principales:	Soo Jin Jeon, Mauricio Elzo, Nicolas DiLorenzo, G Cliff Lamb, Kwang Cheol Jeong
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2013
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/d636cdb175234c5ab116e2311bf0b2c3
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spelling	oai:doaj.org-article:d636cdb175234c5ab116e2311bf0b2c32021-11-18T07:58:32ZEvaluation of animal genetic and physiological factors that affect the prevalence of Escherichia coli O157 in cattle.1932-620310.1371/journal.pone.0055728https://doaj.org/article/d636cdb175234c5ab116e2311bf0b2c32013-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23405204/?tool=EBIhttps://doaj.org/toc/1932-6203Controlling the prevalence of Escherichia coli O157 in cattle at the pre-harvest level is critical to reduce outbreaks of this pathogen in humans. Multilayers of factors including the environmental and bacterial factors modulate the colonization and persistence of E. coli O157 in cattle that serve as a reservoir of this pathogen. Here, we report animal factors contributing to the prevalence of E. coli O157 in cattle. We observe the lowest number of E. coli O157 in Brahman breed when compared with other crosses in an Angus-Brahman multibreed herd, and bulls excrete more E. coli O157 than steers in the pens where cattle were housed together. The presence of super-shedders, cattle excreting >10(5) CFU/rectal anal swab, increases the concentration of E. coli O157 in the pens; thereby super-shedders enhance transmission of this pathogen among cattle. Molecular subtyping analysis reveal only one subtype of E. coli O157 in the multibreed herd, indicating the variance in the levels of E. coli O157 in cattle is influenced by animal factors. Furthermore, strain tracking after relocation of the cattle to a commercial feedlot reveals farm-to-farm transmission of E. coli O157, likely via super-shedders. Our results reveal high risk factors in the prevalence of E. coli O157 in cattle whereby animal genetic and physiological factors influence whether this pathogen can persist in cattle at high concentration, providing insights to intervene this pathogen at the pre-harvest level.Soo Jin JeonMauricio ElzoNicolas DiLorenzoG Cliff LambKwang Cheol JeongPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 8, Iss 2, p e55728 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Soo Jin Jeon Mauricio Elzo Nicolas DiLorenzo G Cliff Lamb Kwang Cheol Jeong Evaluation of animal genetic and physiological factors that affect the prevalence of Escherichia coli O157 in cattle.
description	Controlling the prevalence of Escherichia coli O157 in cattle at the pre-harvest level is critical to reduce outbreaks of this pathogen in humans. Multilayers of factors including the environmental and bacterial factors modulate the colonization and persistence of E. coli O157 in cattle that serve as a reservoir of this pathogen. Here, we report animal factors contributing to the prevalence of E. coli O157 in cattle. We observe the lowest number of E. coli O157 in Brahman breed when compared with other crosses in an Angus-Brahman multibreed herd, and bulls excrete more E. coli O157 than steers in the pens where cattle were housed together. The presence of super-shedders, cattle excreting >10(5) CFU/rectal anal swab, increases the concentration of E. coli O157 in the pens; thereby super-shedders enhance transmission of this pathogen among cattle. Molecular subtyping analysis reveal only one subtype of E. coli O157 in the multibreed herd, indicating the variance in the levels of E. coli O157 in cattle is influenced by animal factors. Furthermore, strain tracking after relocation of the cattle to a commercial feedlot reveals farm-to-farm transmission of E. coli O157, likely via super-shedders. Our results reveal high risk factors in the prevalence of E. coli O157 in cattle whereby animal genetic and physiological factors influence whether this pathogen can persist in cattle at high concentration, providing insights to intervene this pathogen at the pre-harvest level.
format	article
author	Soo Jin Jeon Mauricio Elzo Nicolas DiLorenzo G Cliff Lamb Kwang Cheol Jeong
author_facet	Soo Jin Jeon Mauricio Elzo Nicolas DiLorenzo G Cliff Lamb Kwang Cheol Jeong
author_sort	Soo Jin Jeon
title	Evaluation of animal genetic and physiological factors that affect the prevalence of Escherichia coli O157 in cattle.
title_short	Evaluation of animal genetic and physiological factors that affect the prevalence of Escherichia coli O157 in cattle.
title_full	Evaluation of animal genetic and physiological factors that affect the prevalence of Escherichia coli O157 in cattle.
title_fullStr	Evaluation of animal genetic and physiological factors that affect the prevalence of Escherichia coli O157 in cattle.
title_full_unstemmed	Evaluation of animal genetic and physiological factors that affect the prevalence of Escherichia coli O157 in cattle.
title_sort	evaluation of animal genetic and physiological factors that affect the prevalence of escherichia coli o157 in cattle.
publisher	Public Library of Science (PLoS)
publishDate	2013
url	https://doaj.org/article/d636cdb175234c5ab116e2311bf0b2c3
work_keys_str_mv	AT soojinjeon evaluationofanimalgeneticandphysiologicalfactorsthataffecttheprevalenceofescherichiacolio157incattle AT mauricioelzo evaluationofanimalgeneticandphysiologicalfactorsthataffecttheprevalenceofescherichiacolio157incattle AT nicolasdilorenzo evaluationofanimalgeneticandphysiologicalfactorsthataffecttheprevalenceofescherichiacolio157incattle AT gclifflamb evaluationofanimalgeneticandphysiologicalfactorsthataffecttheprevalenceofescherichiacolio157incattle AT kwangcheoljeong evaluationofanimalgeneticandphysiologicalfactorsthataffecttheprevalenceofescherichiacolio157incattle
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Evaluation of animal genetic and physiological factors that affect the prevalence of Escherichia coli O157 in cattle.

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