WASP-mediated regulation of anti-inflammatory macrophages is IL-10 dependent and is critical for intestinal homeostasis

WASP-mediated regulation of anti-inflammatory macrophages is IL-10 dependent and is critical for intestinal homeostasis

Deficiency in Wiskott-Aldrich syndrome protein (WASP) has been associated with autoimmune colitis, but the underlying mechanism is still unclear. Here the authors show that WASP deficiency is associated with defective WASP/DOCK8 complex formation, altered IL-10 signalling, and impaired anti-inflamma...

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Auteurs principaux: Amlan Biswas, Dror S. Shouval, Alexandra Griffith, Jeremy A. Goettel, Michael Field, Yu Hui Kang, Liza Konnikova, Erin Janssen, Naresh Singh Redhu, Adrian J. Thrasher, Talal Chatila, Vijay K. Kuchroo, Raif S Geha, Luigi D. Notarangelo, Sung-Yun Pai, Bruce H. Horwitz, Scott B. Snapper
Format: article
Langue:EN
Publié: Nature Portfolio 2018
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Science
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Accès en ligne:https://doaj.org/article/d6407c36dbee4770a2372e3380f5d795
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Internet

https://doaj.org/article/d6407c36dbee4770a2372e3380f5d795

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