WASP-mediated regulation of anti-inflammatory macrophages is IL-10 dependent and is critical for intestinal homeostasis

WASP-mediated regulation of anti-inflammatory macrophages is IL-10 dependent and is critical for intestinal homeostasis

Deficiency in Wiskott-Aldrich syndrome protein (WASP) has been associated with autoimmune colitis, but the underlying mechanism is still unclear. Here the authors show that WASP deficiency is associated with defective WASP/DOCK8 complex formation, altered IL-10 signalling, and impaired anti-inflamma...

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Autores principales: Amlan Biswas, Dror S. Shouval, Alexandra Griffith, Jeremy A. Goettel, Michael Field, Yu Hui Kang, Liza Konnikova, Erin Janssen, Naresh Singh Redhu, Adrian J. Thrasher, Talal Chatila, Vijay K. Kuchroo, Raif S Geha, Luigi D. Notarangelo, Sung-Yun Pai, Bruce H. Horwitz, Scott B. Snapper
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Publicado: Nature Portfolio 2018
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Acceso en línea:https://doaj.org/article/d6407c36dbee4770a2372e3380f5d795
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spelling oai:doaj.org-article:d6407c36dbee4770a2372e3380f5d7952021-12-02T14:39:45ZWASP-mediated regulation of anti-inflammatory macrophages is IL-10 dependent and is critical for intestinal homeostasis10.1038/s41467-018-03670-62041-1723https://doaj.org/article/d6407c36dbee4770a2372e3380f5d7952018-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-03670-6https://doaj.org/toc/2041-1723Deficiency in Wiskott-Aldrich syndrome protein (WASP) has been associated with autoimmune colitis, but the underlying mechanism is still unclear. Here the authors show that WASP deficiency is associated with defective WASP/DOCK8 complex formation, altered IL-10 signalling, and impaired anti-inflammatory macrophage functions.Amlan BiswasDror S. ShouvalAlexandra GriffithJeremy A. GoettelMichael FieldYu Hui KangLiza KonnikovaErin JanssenNaresh Singh RedhuAdrian J. ThrasherTalal ChatilaVijay K. KuchrooRaif S GehaLuigi D. NotarangeloSung-Yun PaiBruce H. HorwitzScott B. SnapperNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-15 (2018)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Amlan Biswas
Dror S. Shouval
Alexandra Griffith
Jeremy A. Goettel
Michael Field
Yu Hui Kang
Liza Konnikova
Erin Janssen
Naresh Singh Redhu
Adrian J. Thrasher
Talal Chatila
Vijay K. Kuchroo
Raif S Geha
Luigi D. Notarangelo
Sung-Yun Pai
Bruce H. Horwitz
Scott B. Snapper
WASP-mediated regulation of anti-inflammatory macrophages is IL-10 dependent and is critical for intestinal homeostasis
description Deficiency in Wiskott-Aldrich syndrome protein (WASP) has been associated with autoimmune colitis, but the underlying mechanism is still unclear. Here the authors show that WASP deficiency is associated with defective WASP/DOCK8 complex formation, altered IL-10 signalling, and impaired anti-inflammatory macrophage functions.
format article
author Amlan Biswas
Dror S. Shouval
Alexandra Griffith
Jeremy A. Goettel
Michael Field
Yu Hui Kang
Liza Konnikova
Erin Janssen
Naresh Singh Redhu
Adrian J. Thrasher
Talal Chatila
Vijay K. Kuchroo
Raif S Geha
Luigi D. Notarangelo
Sung-Yun Pai
Bruce H. Horwitz
Scott B. Snapper
author_facet Amlan Biswas
Dror S. Shouval
Alexandra Griffith
Jeremy A. Goettel
Michael Field
Yu Hui Kang
Liza Konnikova
Erin Janssen
Naresh Singh Redhu
Adrian J. Thrasher
Talal Chatila
Vijay K. Kuchroo
Raif S Geha
Luigi D. Notarangelo
Sung-Yun Pai
Bruce H. Horwitz
Scott B. Snapper
author_sort Amlan Biswas
title WASP-mediated regulation of anti-inflammatory macrophages is IL-10 dependent and is critical for intestinal homeostasis
title_short WASP-mediated regulation of anti-inflammatory macrophages is IL-10 dependent and is critical for intestinal homeostasis
title_full WASP-mediated regulation of anti-inflammatory macrophages is IL-10 dependent and is critical for intestinal homeostasis
title_fullStr WASP-mediated regulation of anti-inflammatory macrophages is IL-10 dependent and is critical for intestinal homeostasis
title_full_unstemmed WASP-mediated regulation of anti-inflammatory macrophages is IL-10 dependent and is critical for intestinal homeostasis
title_sort wasp-mediated regulation of anti-inflammatory macrophages is il-10 dependent and is critical for intestinal homeostasis
publisher Nature Portfolio
publishDate 2018
url https://doaj.org/article/d6407c36dbee4770a2372e3380f5d795
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