Base resolution maps reveal the importance of 5-hydroxymethylcytosine in a human glioblastoma

Base resolution maps reveal the importance of 5-hydroxymethylcytosine in a human glioblastoma

Abstract Aberrant genetic and epigenetic variations drive malignant transformation and are hallmarks of cancer. Using PCR-free sample preparation we achieved the first in-depth whole genome (hydroxyl)-methylcytosine, single-base-resolution maps from a glioblastoma tumour/margin sample of a patient....

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Autores principales: Eun-Ang Raiber, Dario Beraldi, Sergio Martínez Cuesta, Gordon R. McInroy, Zoya Kingsbury, Jennifer Becq, Terena James, Margarida Lopes, Kieren Allinson, Sarah Field, Sean Humphray, Thomas Santarius, Colin Watts, David Bentley, Shankar Balasubramanian
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
Materias:
Medicine
R
Genetics
QH426-470
Acceso en línea:https://doaj.org/article/d643e54649364e6b98631c4333afedd9
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https://doaj.org/article/d643e54649364e6b98631c4333afedd9

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