How μ-opioid receptor recognizes fentanyl

Structures of mu-opioid receptor (mOR) in complex with morphine derivatives have been determined; but the structural basis of mOR activation by fentanyl-like synthetic opioids remains unclear. Here, authors use state-of-the-art simulation techniques and discover a secondary binding mode which is onl...

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Auteurs principaux: Quynh N. Vo, Paween Mahinthichaichan, Jana Shen, Christopher R. Ellis
Format: article
Langue:EN
Publié: Nature Portfolio 2021
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Accès en ligne:https://doaj.org/article/d6525e7321244607a119714580e78d1a
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