How μ-opioid receptor recognizes fentanyl

Structures of mu-opioid receptor (mOR) in complex with morphine derivatives have been determined; but the structural basis of mOR activation by fentanyl-like synthetic opioids remains unclear. Here, authors use state-of-the-art simulation techniques and discover a secondary binding mode which is onl...

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Autores principales:	Quynh N. Vo, Paween Mahinthichaichan, Jana Shen, Christopher R. Ellis
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/d6525e7321244607a119714580e78d1a
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id	oai:doaj.org-article:d6525e7321244607a119714580e78d1a
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spelling	oai:doaj.org-article:d6525e7321244607a119714580e78d1a2021-12-02T12:09:31ZHow μ-opioid receptor recognizes fentanyl10.1038/s41467-021-21262-92041-1723https://doaj.org/article/d6525e7321244607a119714580e78d1a2021-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-21262-9https://doaj.org/toc/2041-1723Structures of mu-opioid receptor (mOR) in complex with morphine derivatives have been determined; but the structural basis of mOR activation by fentanyl-like synthetic opioids remains unclear. Here, authors use state-of-the-art simulation techniques and discover a secondary binding mode which is only accessible when the conserved His297 adopts a neutral HID tautomer state.Quynh N. VoPaween MahinthichaichanJana ShenChristopher R. EllisNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Quynh N. Vo Paween Mahinthichaichan Jana Shen Christopher R. Ellis How μ-opioid receptor recognizes fentanyl
description	Structures of mu-opioid receptor (mOR) in complex with morphine derivatives have been determined; but the structural basis of mOR activation by fentanyl-like synthetic opioids remains unclear. Here, authors use state-of-the-art simulation techniques and discover a secondary binding mode which is only accessible when the conserved His297 adopts a neutral HID tautomer state.
format	article
author	Quynh N. Vo Paween Mahinthichaichan Jana Shen Christopher R. Ellis
author_facet	Quynh N. Vo Paween Mahinthichaichan Jana Shen Christopher R. Ellis
author_sort	Quynh N. Vo
title	How μ-opioid receptor recognizes fentanyl
title_short	How μ-opioid receptor recognizes fentanyl
title_full	How μ-opioid receptor recognizes fentanyl
title_fullStr	How μ-opioid receptor recognizes fentanyl
title_full_unstemmed	How μ-opioid receptor recognizes fentanyl
title_sort	how μ-opioid receptor recognizes fentanyl
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/d6525e7321244607a119714580e78d1a
work_keys_str_mv	AT quynhnvo howmopioidreceptorrecognizesfentanyl AT paweenmahinthichaichan howmopioidreceptorrecognizesfentanyl AT janashen howmopioidreceptorrecognizesfentanyl AT christopherrellis howmopioidreceptorrecognizesfentanyl
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How μ-opioid receptor recognizes fentanyl

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