Synergistic catalysis for cascade allylation and 2-aza-cope rearrangement of azomethine ylides

Metallated azomethine ylides are commonly used for the construction of N-heterocycles and α-amino acids. Here, the authors report a synergistic Cu/Ir-catalytic system that converts aldimine esters to a variety of chiral homoallylic amines via a cascade allylation/2-aza-Cope rearrangement.

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Autores principales:	Liang Wei, Qiao Zhu, Lu Xiao, Hai-Yan Tao, Chun-Jiang Wang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/d66f8b0ef64849baa3af7b38ea218790
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spelling	oai:doaj.org-article:d66f8b0ef64849baa3af7b38ea2187902021-12-02T14:38:59ZSynergistic catalysis for cascade allylation and 2-aza-cope rearrangement of azomethine ylides10.1038/s41467-019-09563-62041-1723https://doaj.org/article/d66f8b0ef64849baa3af7b38ea2187902019-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-09563-6https://doaj.org/toc/2041-1723Metallated azomethine ylides are commonly used for the construction of N-heterocycles and α-amino acids. Here, the authors report a synergistic Cu/Ir-catalytic system that converts aldimine esters to a variety of chiral homoallylic amines via a cascade allylation/2-aza-Cope rearrangement.Liang WeiQiao ZhuLu XiaoHai-Yan TaoChun-Jiang WangNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-12 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Liang Wei Qiao Zhu Lu Xiao Hai-Yan Tao Chun-Jiang Wang Synergistic catalysis for cascade allylation and 2-aza-cope rearrangement of azomethine ylides
description	Metallated azomethine ylides are commonly used for the construction of N-heterocycles and α-amino acids. Here, the authors report a synergistic Cu/Ir-catalytic system that converts aldimine esters to a variety of chiral homoallylic amines via a cascade allylation/2-aza-Cope rearrangement.
format	article
author	Liang Wei Qiao Zhu Lu Xiao Hai-Yan Tao Chun-Jiang Wang
author_facet	Liang Wei Qiao Zhu Lu Xiao Hai-Yan Tao Chun-Jiang Wang
author_sort	Liang Wei
title	Synergistic catalysis for cascade allylation and 2-aza-cope rearrangement of azomethine ylides
title_short	Synergistic catalysis for cascade allylation and 2-aza-cope rearrangement of azomethine ylides
title_full	Synergistic catalysis for cascade allylation and 2-aza-cope rearrangement of azomethine ylides
title_fullStr	Synergistic catalysis for cascade allylation and 2-aza-cope rearrangement of azomethine ylides
title_full_unstemmed	Synergistic catalysis for cascade allylation and 2-aza-cope rearrangement of azomethine ylides
title_sort	synergistic catalysis for cascade allylation and 2-aza-cope rearrangement of azomethine ylides
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/d66f8b0ef64849baa3af7b38ea218790
work_keys_str_mv	AT liangwei synergisticcatalysisforcascadeallylationand2azacoperearrangementofazomethineylides AT qiaozhu synergisticcatalysisforcascadeallylationand2azacoperearrangementofazomethineylides AT luxiao synergisticcatalysisforcascadeallylationand2azacoperearrangementofazomethineylides AT haiyantao synergisticcatalysisforcascadeallylationand2azacoperearrangementofazomethineylides AT chunjiangwang synergisticcatalysisforcascadeallylationand2azacoperearrangementofazomethineylides
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Synergistic catalysis for cascade allylation and 2-aza-cope rearrangement of azomethine ylides

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