Regulation of Angiopoietin Signalling by Soluble Tie2 Ectodomain and Engineered Ligand Trap

Abstract Angiopoietin-1 (Angpt1) is a glycoprotein ligand important for maintaining the vascular system. It signals via a receptor tyrosine kinase expressed on the surface on endothelial cells, Tie2. This receptor can undergo regulated ectodomain cleavage that releases the ligand-binding domain (sTi...

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Autores principales: Deborah O. A. Alawo, Tariq A. Tahir, Marlies Fischer, Declan G. Bates, Svetlana R. Amirova, Nicholas P. J. Brindle
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
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Acceso en línea:https://doaj.org/article/d67adf71f1c94acdaa76476210bf82b7
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