Bedaquiline reprograms central metabolism to reveal glycolytic vulnerability in Mycobacterium tuberculosis

Bedaquiline (BDQ) is a known tuberculosis treatment, but the precise mechanism of cell death is unclear. Here, the authors explore the metabolic profiles of M. tuberculosis upon BDQ treatment and find reliance on glycolysis and synergistic cell death when oxidative phosphorylation is also targeted.

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Autores principales:	Jared S. Mackenzie, Dirk A. Lamprecht, Rukaya Asmal, John H. Adamson, Khushboo Borah, Dany J. V. Beste, Bei Shi Lee, Kevin Pethe, Simon Rousseau, Inna Krieger, James C. Sacchettini, Joel N. Glasgow, Adrie J. C. Steyn
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/d680f868a7c742a69cdc3f6e9206d15b
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spelling	oai:doaj.org-article:d680f868a7c742a69cdc3f6e9206d15b2021-12-02T14:40:39ZBedaquiline reprograms central metabolism to reveal glycolytic vulnerability in Mycobacterium tuberculosis10.1038/s41467-020-19959-42041-1723https://doaj.org/article/d680f868a7c742a69cdc3f6e9206d15b2020-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-19959-4https://doaj.org/toc/2041-1723Bedaquiline (BDQ) is a known tuberculosis treatment, but the precise mechanism of cell death is unclear. Here, the authors explore the metabolic profiles of M. tuberculosis upon BDQ treatment and find reliance on glycolysis and synergistic cell death when oxidative phosphorylation is also targeted.Jared S. MackenzieDirk A. LamprechtRukaya AsmalJohn H. AdamsonKhushboo BorahDany J. V. BesteBei Shi LeeKevin PetheSimon RousseauInna KriegerJames C. SacchettiniJoel N. GlasgowAdrie J. C. SteynNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Jared S. Mackenzie Dirk A. Lamprecht Rukaya Asmal John H. Adamson Khushboo Borah Dany J. V. Beste Bei Shi Lee Kevin Pethe Simon Rousseau Inna Krieger James C. Sacchettini Joel N. Glasgow Adrie J. C. Steyn Bedaquiline reprograms central metabolism to reveal glycolytic vulnerability in Mycobacterium tuberculosis
description	Bedaquiline (BDQ) is a known tuberculosis treatment, but the precise mechanism of cell death is unclear. Here, the authors explore the metabolic profiles of M. tuberculosis upon BDQ treatment and find reliance on glycolysis and synergistic cell death when oxidative phosphorylation is also targeted.
format	article
author	Jared S. Mackenzie Dirk A. Lamprecht Rukaya Asmal John H. Adamson Khushboo Borah Dany J. V. Beste Bei Shi Lee Kevin Pethe Simon Rousseau Inna Krieger James C. Sacchettini Joel N. Glasgow Adrie J. C. Steyn
author_facet	Jared S. Mackenzie Dirk A. Lamprecht Rukaya Asmal John H. Adamson Khushboo Borah Dany J. V. Beste Bei Shi Lee Kevin Pethe Simon Rousseau Inna Krieger James C. Sacchettini Joel N. Glasgow Adrie J. C. Steyn
author_sort	Jared S. Mackenzie
title	Bedaquiline reprograms central metabolism to reveal glycolytic vulnerability in Mycobacterium tuberculosis
title_short	Bedaquiline reprograms central metabolism to reveal glycolytic vulnerability in Mycobacterium tuberculosis
title_full	Bedaquiline reprograms central metabolism to reveal glycolytic vulnerability in Mycobacterium tuberculosis
title_fullStr	Bedaquiline reprograms central metabolism to reveal glycolytic vulnerability in Mycobacterium tuberculosis
title_full_unstemmed	Bedaquiline reprograms central metabolism to reveal glycolytic vulnerability in Mycobacterium tuberculosis
title_sort	bedaquiline reprograms central metabolism to reveal glycolytic vulnerability in mycobacterium tuberculosis
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/d680f868a7c742a69cdc3f6e9206d15b
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Bedaquiline reprograms central metabolism to reveal glycolytic vulnerability in Mycobacterium tuberculosis

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