Hierarchical control on polyene macrolide biosynthesis: PimR modulates pimaricin production via the PAS-LuxR transcriptional activator PimM.

Control of polyene macrolide production in Streptomyces natalensis is mediated by the transcriptional activator PimR. This regulator combines an N-terminal domain corresponding to the Streptomyces antibiotic regulatory protein (SARP) family of transcriptional activators with a C-terminal half homolo...

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Autores principales: Javier Santos-Aberturas, Cláudia M Vicente, Tamara D Payero, Lara Martín-Sánchez, Carmen Cañibano, Juan F Martín, Jesús F Aparicio
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2012
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Acceso en línea:https://doaj.org/article/d6846085a137452284e13b06761630f0
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