LITESEC-T3SS - Light-controlled protein delivery into eukaryotic cells with high spatial and temporal resolution

The type III secretion system (T3SS) of bacteria can be used to inject cargo into eukaryotic cells but its lack of target specificity is a disadvantage. Here the authors place the T3SS under the regulation of light by engineering optogenetic switches into the dynamic cytosolic T3SS component SctQ.

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Autores principales:	Florian Lindner, Bailey Milne-Davies, Katja Langenfeld, Thorsten Stiewe, Andreas Diepold
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/d6971f55f08f4ba59594684ea20501bc
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spelling	oai:doaj.org-article:d6971f55f08f4ba59594684ea20501bc2021-12-02T16:50:20ZLITESEC-T3SS - Light-controlled protein delivery into eukaryotic cells with high spatial and temporal resolution10.1038/s41467-020-16169-w2041-1723https://doaj.org/article/d6971f55f08f4ba59594684ea20501bc2020-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-16169-whttps://doaj.org/toc/2041-1723The type III secretion system (T3SS) of bacteria can be used to inject cargo into eukaryotic cells but its lack of target specificity is a disadvantage. Here the authors place the T3SS under the regulation of light by engineering optogenetic switches into the dynamic cytosolic T3SS component SctQ.Florian LindnerBailey Milne-DaviesKatja LangenfeldThorsten StieweAndreas DiepoldNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Florian Lindner Bailey Milne-Davies Katja Langenfeld Thorsten Stiewe Andreas Diepold LITESEC-T3SS - Light-controlled protein delivery into eukaryotic cells with high spatial and temporal resolution
description	The type III secretion system (T3SS) of bacteria can be used to inject cargo into eukaryotic cells but its lack of target specificity is a disadvantage. Here the authors place the T3SS under the regulation of light by engineering optogenetic switches into the dynamic cytosolic T3SS component SctQ.
format	article
author	Florian Lindner Bailey Milne-Davies Katja Langenfeld Thorsten Stiewe Andreas Diepold
author_facet	Florian Lindner Bailey Milne-Davies Katja Langenfeld Thorsten Stiewe Andreas Diepold
author_sort	Florian Lindner
title	LITESEC-T3SS - Light-controlled protein delivery into eukaryotic cells with high spatial and temporal resolution
title_short	LITESEC-T3SS - Light-controlled protein delivery into eukaryotic cells with high spatial and temporal resolution
title_full	LITESEC-T3SS - Light-controlled protein delivery into eukaryotic cells with high spatial and temporal resolution
title_fullStr	LITESEC-T3SS - Light-controlled protein delivery into eukaryotic cells with high spatial and temporal resolution
title_full_unstemmed	LITESEC-T3SS - Light-controlled protein delivery into eukaryotic cells with high spatial and temporal resolution
title_sort	litesec-t3ss - light-controlled protein delivery into eukaryotic cells with high spatial and temporal resolution
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/d6971f55f08f4ba59594684ea20501bc
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LITESEC-T3SS - Light-controlled protein delivery into eukaryotic cells with high spatial and temporal resolution

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