Restoration of the healing microenvironment in diabetic wounds with matrix-binding IL-1 receptor antagonist

Tan, Lash et al. show that blocking the Interleukin-1 receptor promotes rapid wound closure in diabetic mice. They engineered a matrix binding form of Interleukin-1 receptor antagonist (IL-1Ra) that has the ability of precise localisation and retention in the tissue. IL-1Ra holds the potential for e...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Jean L. Tan, Blake Lash, Rezvan Karami, Bhavana Nayer, Yen-Zhen Lu, Celeste Piotto, Ziad Julier, Mikaël M. Martino
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/d69e7e9bda4641d3aec93935b49ff999
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:d69e7e9bda4641d3aec93935b49ff999
record_format	dspace
spelling	oai:doaj.org-article:d69e7e9bda4641d3aec93935b49ff9992021-12-02T11:45:00ZRestoration of the healing microenvironment in diabetic wounds with matrix-binding IL-1 receptor antagonist10.1038/s42003-021-01913-92399-3642https://doaj.org/article/d69e7e9bda4641d3aec93935b49ff9992021-03-01T00:00:00Zhttps://doi.org/10.1038/s42003-021-01913-9https://doaj.org/toc/2399-3642Tan, Lash et al. show that blocking the Interleukin-1 receptor promotes rapid wound closure in diabetic mice. They engineered a matrix binding form of Interleukin-1 receptor antagonist (IL-1Ra) that has the ability of precise localisation and retention in the tissue. IL-1Ra holds the potential for expediting wound healing in diabetic patients.Jean L. TanBlake LashRezvan KaramiBhavana NayerYen-Zhen LuCeleste PiottoZiad JulierMikaël M. MartinoNature PortfolioarticleBiology (General)QH301-705.5ENCommunications Biology, Vol 4, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Jean L. Tan Blake Lash Rezvan Karami Bhavana Nayer Yen-Zhen Lu Celeste Piotto Ziad Julier Mikaël M. Martino Restoration of the healing microenvironment in diabetic wounds with matrix-binding IL-1 receptor antagonist
description	Tan, Lash et al. show that blocking the Interleukin-1 receptor promotes rapid wound closure in diabetic mice. They engineered a matrix binding form of Interleukin-1 receptor antagonist (IL-1Ra) that has the ability of precise localisation and retention in the tissue. IL-1Ra holds the potential for expediting wound healing in diabetic patients.
format	article
author	Jean L. Tan Blake Lash Rezvan Karami Bhavana Nayer Yen-Zhen Lu Celeste Piotto Ziad Julier Mikaël M. Martino
author_facet	Jean L. Tan Blake Lash Rezvan Karami Bhavana Nayer Yen-Zhen Lu Celeste Piotto Ziad Julier Mikaël M. Martino
author_sort	Jean L. Tan
title	Restoration of the healing microenvironment in diabetic wounds with matrix-binding IL-1 receptor antagonist
title_short	Restoration of the healing microenvironment in diabetic wounds with matrix-binding IL-1 receptor antagonist
title_full	Restoration of the healing microenvironment in diabetic wounds with matrix-binding IL-1 receptor antagonist
title_fullStr	Restoration of the healing microenvironment in diabetic wounds with matrix-binding IL-1 receptor antagonist
title_full_unstemmed	Restoration of the healing microenvironment in diabetic wounds with matrix-binding IL-1 receptor antagonist
title_sort	restoration of the healing microenvironment in diabetic wounds with matrix-binding il-1 receptor antagonist
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/d69e7e9bda4641d3aec93935b49ff999
work_keys_str_mv	AT jeanltan restorationofthehealingmicroenvironmentindiabeticwoundswithmatrixbindingil1receptorantagonist AT blakelash restorationofthehealingmicroenvironmentindiabeticwoundswithmatrixbindingil1receptorantagonist AT rezvankarami restorationofthehealingmicroenvironmentindiabeticwoundswithmatrixbindingil1receptorantagonist AT bhavananayer restorationofthehealingmicroenvironmentindiabeticwoundswithmatrixbindingil1receptorantagonist AT yenzhenlu restorationofthehealingmicroenvironmentindiabeticwoundswithmatrixbindingil1receptorantagonist AT celestepiotto restorationofthehealingmicroenvironmentindiabeticwoundswithmatrixbindingil1receptorantagonist AT ziadjulier restorationofthehealingmicroenvironmentindiabeticwoundswithmatrixbindingil1receptorantagonist AT mikaelmmartino restorationofthehealingmicroenvironmentindiabeticwoundswithmatrixbindingil1receptorantagonist
_version_	1718395312788209664

Restoration of the healing microenvironment in diabetic wounds with matrix-binding IL-1 receptor antagonist

Ejemplares similares