Restoration of the healing microenvironment in diabetic wounds with matrix-binding IL-1 receptor antagonist

Tan, Lash et al. show that blocking the Interleukin-1 receptor promotes rapid wound closure in diabetic mice. They engineered a matrix binding form of Interleukin-1 receptor antagonist (IL-1Ra) that has the ability of precise localisation and retention in the tissue. IL-1Ra holds the potential for e...

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Bibliographic Details
Main Authors: Jean L. Tan, Blake Lash, Rezvan Karami, Bhavana Nayer, Yen-Zhen Lu, Celeste Piotto, Ziad Julier, Mikaël M. Martino
Format: article
Language:EN
Published: Nature Portfolio 2021
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Online Access:https://doaj.org/article/d69e7e9bda4641d3aec93935b49ff999
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