Involvement of condensin in cellular senescence through gene regulation and compartmental reorganization

Cell senescence involves stable arrest of cell proliferation and changes in gene expression and 3D genome reorganization. Here, the authors show that human condensin II complex participates in reorganization of the chromatin compartments, primarily through switching from heterochromatic B to euchrom...

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Main Authors: Osamu Iwasaki, Hideki Tanizawa, Kyoung-Dong Kim, Andrew Kossenkov, Timothy Nacarelli, Sanki Tashiro, Sonali Majumdar, Louise C. Showe, Rugang Zhang, Ken-ichi Noma
Format: article
Language:EN
Published: Nature Portfolio 2019
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Online Access:https://doaj.org/article/d6bfd9f78d8e46fe944d870a5010386b
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