Neutrophil extracellular trap formation requires OPA1-dependent glycolytic ATP production

Neutrophil extracellular trap formation requires OPA1-dependent glycolytic ATP production

Optic atrophy 1 (OPA1) is known to be important for mitochondrial fusion and structural integrity. Here, using OPA1 knockout mice, the authors show a detrimental effect on host defense capabilities against pathogen infections. This study reports a critical role for OPA1 in innate immunity.

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Auteurs principaux: Poorya Amini, Darko Stojkov, Andrea Felser, Christopher B. Jackson, Carolina Courage, André Schaller, Laurent Gelman, Maria Eugenia Soriano, Jean-Marc Nuoffer, Luca Scorrano, Charaf Benarafa, Shida Yousefi, Hans-Uwe Simon
Format: article
Langue:EN
Publié: Nature Portfolio 2018
Sujets:
Science
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Accès en ligne:https://doaj.org/article/d6d65756387f4a38a5e16d6f0ce5f658
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https://doaj.org/article/d6d65756387f4a38a5e16d6f0ce5f658

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