Neutrophil extracellular trap formation requires OPA1-dependent glycolytic ATP production

Optic atrophy 1 (OPA1) is known to be important for mitochondrial fusion and structural integrity. Here, using OPA1 knockout mice, the authors show a detrimental effect on host defense capabilities against pathogen infections. This study reports a critical role for OPA1 in innate immunity.

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Autores principales:	Poorya Amini, Darko Stojkov, Andrea Felser, Christopher B. Jackson, Carolina Courage, André Schaller, Laurent Gelman, Maria Eugenia Soriano, Jean-Marc Nuoffer, Luca Scorrano, Charaf Benarafa, Shida Yousefi, Hans-Uwe Simon
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/d6d65756387f4a38a5e16d6f0ce5f658
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spelling	oai:doaj.org-article:d6d65756387f4a38a5e16d6f0ce5f6582021-12-02T16:49:56ZNeutrophil extracellular trap formation requires OPA1-dependent glycolytic ATP production10.1038/s41467-018-05387-y2041-1723https://doaj.org/article/d6d65756387f4a38a5e16d6f0ce5f6582018-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-05387-yhttps://doaj.org/toc/2041-1723Optic atrophy 1 (OPA1) is known to be important for mitochondrial fusion and structural integrity. Here, using OPA1 knockout mice, the authors show a detrimental effect on host defense capabilities against pathogen infections. This study reports a critical role for OPA1 in innate immunity.Poorya AminiDarko StojkovAndrea FelserChristopher B. JacksonCarolina CourageAndré SchallerLaurent GelmanMaria Eugenia SorianoJean-Marc NuofferLuca ScorranoCharaf BenarafaShida YousefiHans-Uwe SimonNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-16 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Poorya Amini Darko Stojkov Andrea Felser Christopher B. Jackson Carolina Courage André Schaller Laurent Gelman Maria Eugenia Soriano Jean-Marc Nuoffer Luca Scorrano Charaf Benarafa Shida Yousefi Hans-Uwe Simon Neutrophil extracellular trap formation requires OPA1-dependent glycolytic ATP production
description	Optic atrophy 1 (OPA1) is known to be important for mitochondrial fusion and structural integrity. Here, using OPA1 knockout mice, the authors show a detrimental effect on host defense capabilities against pathogen infections. This study reports a critical role for OPA1 in innate immunity.
format	article
author	Poorya Amini Darko Stojkov Andrea Felser Christopher B. Jackson Carolina Courage André Schaller Laurent Gelman Maria Eugenia Soriano Jean-Marc Nuoffer Luca Scorrano Charaf Benarafa Shida Yousefi Hans-Uwe Simon
author_facet	Poorya Amini Darko Stojkov Andrea Felser Christopher B. Jackson Carolina Courage André Schaller Laurent Gelman Maria Eugenia Soriano Jean-Marc Nuoffer Luca Scorrano Charaf Benarafa Shida Yousefi Hans-Uwe Simon
author_sort	Poorya Amini
title	Neutrophil extracellular trap formation requires OPA1-dependent glycolytic ATP production
title_short	Neutrophil extracellular trap formation requires OPA1-dependent glycolytic ATP production
title_full	Neutrophil extracellular trap formation requires OPA1-dependent glycolytic ATP production
title_fullStr	Neutrophil extracellular trap formation requires OPA1-dependent glycolytic ATP production
title_full_unstemmed	Neutrophil extracellular trap formation requires OPA1-dependent glycolytic ATP production
title_sort	neutrophil extracellular trap formation requires opa1-dependent glycolytic atp production
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/d6d65756387f4a38a5e16d6f0ce5f658
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Neutrophil extracellular trap formation requires OPA1-dependent glycolytic ATP production

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