Influenza Virus Hemagglutinin Stalk-Specific Antibodies in Human Serum are a Surrogate Marker for <italic toggle="yes">In Vivo</italic> Protection in a Serum Transfer Mouse Challenge Model

Influenza Virus Hemagglutinin Stalk-Specific Antibodies in Human Serum are a Surrogate Marker for <italic toggle="yes">In Vivo</italic> Protection in a Serum Transfer Mouse Challenge Model

ABSTRACT The immunogenicity of current influenza virus vaccines is assessed by measuring an increase of influenza virus-specific antibodies in a hemagglutination inhibition assay. This method exclusively measures antibodies against the hemagglutinin head domain. While this domain is immunodominant,...

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Autores principales: Henning Jacobsen, Madhusudan Rajendran, Angela Choi, Haakon Sjursen, Karl A. Brokstad, Rebecca J. Cox, Peter Palese, Florian Krammer, Raffael Nachbagauer
Formato: article
Lenguaje:EN
Publicado: American Society for Microbiology 2017
Materias:
ADCC
ELISA
correlate of protection
hemagglutinin
hemagglutinin stalk
influenza
Microbiology
QR1-502
Acceso en línea:https://doaj.org/article/d709eec0ace54c98a0b1c220de07b37d
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https://doaj.org/article/d709eec0ace54c98a0b1c220de07b37d

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