Conformational switching in the coiled-coil domains of a proteasomal ATPase regulates substrate processing

Proteasomal ATPases contain functionally important coiled-coil (CC) domains, the mechanistic role of which is not fully understood. Here, the authors provide evidence for three distinct CC conformations, showing that CC conformational changes enable ATPases to switch between active and resting state...

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Autores principales:	Aaron Snoberger, Evan J. Brettrager, David M. Smith
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/d753a210f94644cf8f78d72fae386d53
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spelling	oai:doaj.org-article:d753a210f94644cf8f78d72fae386d532021-12-02T15:34:27ZConformational switching in the coiled-coil domains of a proteasomal ATPase regulates substrate processing10.1038/s41467-018-04731-62041-1723https://doaj.org/article/d753a210f94644cf8f78d72fae386d532018-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-04731-6https://doaj.org/toc/2041-1723Proteasomal ATPases contain functionally important coiled-coil (CC) domains, the mechanistic role of which is not fully understood. Here, the authors provide evidence for three distinct CC conformations, showing that CC conformational changes enable ATPases to switch between active and resting states.Aaron SnobergerEvan J. BrettragerDavid M. SmithNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Aaron Snoberger Evan J. Brettrager David M. Smith Conformational switching in the coiled-coil domains of a proteasomal ATPase regulates substrate processing
description	Proteasomal ATPases contain functionally important coiled-coil (CC) domains, the mechanistic role of which is not fully understood. Here, the authors provide evidence for three distinct CC conformations, showing that CC conformational changes enable ATPases to switch between active and resting states.
format	article
author	Aaron Snoberger Evan J. Brettrager David M. Smith
author_facet	Aaron Snoberger Evan J. Brettrager David M. Smith
author_sort	Aaron Snoberger
title	Conformational switching in the coiled-coil domains of a proteasomal ATPase regulates substrate processing
title_short	Conformational switching in the coiled-coil domains of a proteasomal ATPase regulates substrate processing
title_full	Conformational switching in the coiled-coil domains of a proteasomal ATPase regulates substrate processing
title_fullStr	Conformational switching in the coiled-coil domains of a proteasomal ATPase regulates substrate processing
title_full_unstemmed	Conformational switching in the coiled-coil domains of a proteasomal ATPase regulates substrate processing
title_sort	conformational switching in the coiled-coil domains of a proteasomal atpase regulates substrate processing
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/d753a210f94644cf8f78d72fae386d53
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_version_	1718386867027574784

Conformational switching in the coiled-coil domains of a proteasomal ATPase regulates substrate processing

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