The structural basis of gas-responsive transcription by the human nuclear hormone receptor REV-ERBbeta.

Heme is a ligand for the human nuclear receptors (NR) REV-ERBalpha and REV-ERBbeta, which are transcriptional repressors that play important roles in circadian rhythm, lipid and glucose metabolism, and diseases such as diabetes, atherosclerosis, inflammation, and cancer. Here we show that transcript...

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Autores principales: Keith I Pardee, Xiaohui Xu, Jeff Reinking, Anja Schuetz, Aiping Dong, Suya Liu, Rongguang Zhang, Jens Tiefenbach, Gilles Lajoie, Alexander N Plotnikov, Alexey Botchkarev, Henry M Krause, Aled Edwards
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2009
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Acceso en línea:https://doaj.org/article/d76afef7ed9440828f6f21f6b78d7b15
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