Split Intein-Mediated Protein Ligation for detecting protein-protein interactions and their inhibition

Protein-protein interactions are fundamental to the regulation of protein activity and cellular phyisology. Here the authors present Split Intein-Mediated Protein Ligation, which uses bait and prey proteins fused to intein fragments to generate single intact proteins upon interaction.

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Autores principales:	Zhong Yao, Farzaneh Aboualizadeh, Jason Kroll, Indira Akula, Jamie Snider, Anna Lyakisheva, Priscilla Tang, Max Kotlyar, Igor Jurisica, Mike Boxem, Igor Stagljar
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/d7c200701845452a9c8b0403041b6f6f
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spelling	oai:doaj.org-article:d7c200701845452a9c8b0403041b6f6f2021-12-02T15:54:49ZSplit Intein-Mediated Protein Ligation for detecting protein-protein interactions and their inhibition10.1038/s41467-020-16299-12041-1723https://doaj.org/article/d7c200701845452a9c8b0403041b6f6f2020-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-16299-1https://doaj.org/toc/2041-1723Protein-protein interactions are fundamental to the regulation of protein activity and cellular phyisology. Here the authors present Split Intein-Mediated Protein Ligation, which uses bait and prey proteins fused to intein fragments to generate single intact proteins upon interaction.Zhong YaoFarzaneh AboualizadehJason KrollIndira AkulaJamie SniderAnna LyakishevaPriscilla TangMax KotlyarIgor JurisicaMike BoxemIgor StagljarNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Zhong Yao Farzaneh Aboualizadeh Jason Kroll Indira Akula Jamie Snider Anna Lyakisheva Priscilla Tang Max Kotlyar Igor Jurisica Mike Boxem Igor Stagljar Split Intein-Mediated Protein Ligation for detecting protein-protein interactions and their inhibition
description	Protein-protein interactions are fundamental to the regulation of protein activity and cellular phyisology. Here the authors present Split Intein-Mediated Protein Ligation, which uses bait and prey proteins fused to intein fragments to generate single intact proteins upon interaction.
format	article
author	Zhong Yao Farzaneh Aboualizadeh Jason Kroll Indira Akula Jamie Snider Anna Lyakisheva Priscilla Tang Max Kotlyar Igor Jurisica Mike Boxem Igor Stagljar
author_facet	Zhong Yao Farzaneh Aboualizadeh Jason Kroll Indira Akula Jamie Snider Anna Lyakisheva Priscilla Tang Max Kotlyar Igor Jurisica Mike Boxem Igor Stagljar
author_sort	Zhong Yao
title	Split Intein-Mediated Protein Ligation for detecting protein-protein interactions and their inhibition
title_short	Split Intein-Mediated Protein Ligation for detecting protein-protein interactions and their inhibition
title_full	Split Intein-Mediated Protein Ligation for detecting protein-protein interactions and their inhibition
title_fullStr	Split Intein-Mediated Protein Ligation for detecting protein-protein interactions and their inhibition
title_full_unstemmed	Split Intein-Mediated Protein Ligation for detecting protein-protein interactions and their inhibition
title_sort	split intein-mediated protein ligation for detecting protein-protein interactions and their inhibition
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/d7c200701845452a9c8b0403041b6f6f
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Split Intein-Mediated Protein Ligation for detecting protein-protein interactions and their inhibition

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