Humanization of Antibodies using a Statistical Inference Approach

Abstract Antibody humanization is a key step in the preclinical phase of the development of therapeutic antibodies, originally developed and tested in non-human models (most typically, in mouse). The standard technique of Complementarity-Determining Regions (CDR) grafting into human Framework Region...

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Auteurs principaux: Alejandro Clavero-Álvarez, Tomas Di Mambro, Sergio Perez-Gaviro, Mauro Magnani, Pierpaolo Bruscolini
Format: article
Langue:EN
Publié: Nature Portfolio 2018
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R
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Accès en ligne:https://doaj.org/article/d7d0d04158114730870c611335bc2747
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