Humanization of Antibodies using a Statistical Inference Approach
Abstract Antibody humanization is a key step in the preclinical phase of the development of therapeutic antibodies, originally developed and tested in non-human models (most typically, in mouse). The standard technique of Complementarity-Determining Regions (CDR) grafting into human Framework Region...
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Autores principales: | Alejandro Clavero-Álvarez, Tomas Di Mambro, Sergio Perez-Gaviro, Mauro Magnani, Pierpaolo Bruscolini |
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Formato: | article |
Lenguaje: | EN |
Publicado: |
Nature Portfolio
2018
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Materias: | |
Acceso en línea: | https://doaj.org/article/d7d0d04158114730870c611335bc2747 |
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