Fluorescent thermal shift-based method for detection of NF-κB binding to double-stranded DNA

Abstract The nuclear factor kappa B (NF-κB) family of dimeric transcription factors regulates a wide range of genes by binding to their specific DNA regulatory sequences. NF-κB is an important therapeutic target linked to a number of cancers as well as autoimmune and inflammatory diseases. Therefore...

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Autores principales: Peter D. Leitner, Ilja Vietor, Lukas A. Huber, Taras Valovka
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/d7d7351fa7fa4902828aa877384f06ac
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