A non-canonical role for the autophagy machinery in anti-retroviral signaling mediated by TRIM5α.

TRIM5α is a key cross-species barrier to retroviral infection, with certain TRIM5 alleles conferring increased risk of HIV-1 infection in humans. TRIM5α is best known as a species-specific restriction factor that directly inhibits the viral life cycle. Additionally, it is also a pattern-recognition...

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Autores principales: Bhaskar Saha, Devon Chisholm, Alison M Kell, Michael A Mandell
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2020
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Acceso en línea:https://doaj.org/article/d8319a2ceeae4321ab676ebe44cf7a7e
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